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Sequential chemoimmunotherapy for advanced non-small cell lung cancer using cisplatin, etoposide, thymosin-alpha 1 and interferon-alpha 2a.
使用顺铂、依托泊苷、胸腺肽-α 1 和干扰素-α 2a 对晚期非小细胞肺癌进行序贯化学免疫治疗。

摘要

A phase II study was performed to evaluate the clinical and immunological effects of a regimen of cisplatin (DDP) and etoposide (VP-16) combined with thymosin-alpha 1 (TA1) and low-dose interferon-alpha 2a (IFN) in the treatment of patients with advanced non-small cell lung cancer (NSCLC). Chemoimmunotherapy cycles were repeated every 3 weeks. There were 24 responses (two complete, 22 partial) among 56 assessable patients. Median survival was 12.6 months. Overall, treatment was well tolerated. Natural killer cell activity and lymphocyte subtypes were depressed by chemotherapy, but this effect was less prominent in patients receiving TA1 and IFN in comparison with a concomitant group of patients treated with DDP and VP-16 only. The combination of DDP and VP-16 and TA1 and IFN is effective in advanced NSCLC with acceptable toxicity. However, the results of this study need to be confirmed in a randomised trial.

译文

进行了一项 II 期研究,以评估顺铂 (DDP) 和依托泊苷 (VP-16) 联合胸腺肽-α 1 (TA1) 方案的临床和免疫学效果。和低剂量干扰素-α 2a (IFN) 治疗晚期非小细胞肺癌 (NSCLC) 患者。每 3 周重复化疗免疫治疗周期。在 56 个可评估的患者中有 24 个反应 (两个完全,22 个部分)。中位生存期为 12.6 个月。总的来说,治疗耐受性良好。化疗抑制了自然杀伤细胞活性和淋巴细胞亚型,但与仅接受 DDP 和 VP-16 治疗的同时接受 TA1 和 IFN 治疗的患者相比,这种影响在接受 TA1 和 IFN 治疗的患者中并不突出。DDP 和 VP-16 以及 TA1 和 IFN 的联合使用在毒性可接受的晚期非小细胞肺癌中是有效的。然而,这项研究的结果需要在随机试验中得到证实。

Thymosin Alpha 1

重症 治疗慢性乙型肝炎 药物
概述  :  

胸腺肽α1自上世纪70年代被纯化后,作为免疫增强剂被逐渐应用在临床治疗上,进口制剂为日达仙,在恶性肿瘤和慢性病毒性肝炎和自身免疫性疾病的治疗上发挥了较好疗效。近年来国产胸腺肽α1除应用在肿瘤及肝病治疗上外,在慢性感染性疾病中如慢性阻塞性肺疾病、脓毒血症亦显示了较好的前景。 作用机制胸腺肽α1是胸腺产生的一种蛋白质和多肽激素,可提高自然杀伤细胞的分化和活性,促使T细胞分化成熟,增加T细胞前体数量,并进一步分化为T细胞不同功能的亚群,增加CD4 + 和CD8 + T细胞的产生并维持CD

thymosin ['θaɪməsɪn]

释义   n. 胸腺素

例句   In comparison with cow thymosin, the main characteristic was the same.与牛胸腺素相比,其主要特征相同。

 

Alpha [ˈælfə]

释义   n. 希腊语的第一个字母

例句   And let me tell you a little bit about alpha.让我告诉你一点点关于阿尔法常数的事。


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