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首页 > 医学词汇大全 > Acute hepatic failure
Acute hepatic failure

重症

关键词重症 疾病 肝衰竭

词汇介绍

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解析

acute 英 [əˈkju:t] 美 [əˈkju:t]

释义   adj. 严重的,[医] 急性的;敏锐的;激烈的;尖声的

例句   He is an acute observer.他是一个敏锐的观察者。

 

hepatic 英 [hɪˈpætɪk] 美 [hɪˈpætɪk]

释义   adj. 肝的;肝脏色的;治肝病的

例句   AIM: To investigate the role of resistin in hepatic insulin resistance and its mechanism.目的:探讨抵抗素在肝脏胰岛素抵抗中的作用及其机制。

 

failure 英 [ˈfeɪljə(r)] 美 [ˈfeɪljər]

释义   n. 失败;故障;失败者;破产

例句   You have to have success and failure.你必须经受成功和失败。


概述

急性肝衰竭是由由病毒、细菌感染以及药物、酒精中毒等各种不同病因引起的严重肝损伤,导致肝脏的合成、解毒、排泄和生物转化功能发生严重障碍或失代偿,出现以凝血机制障碍、黄疸、肝性脑病和腹水等为主要表现的一组临床症候群。在中国,HBV是导致肝衰竭最常见的病因。 病理机制急性肝衰竭病理学基础为:一次性打击的一致性的大块性(>2/3肝小叶)或亚大块性坏死(1/3~2/3肝小叶),网状支架不塌陷或少量不完全性塌陷。坏死区肝窦扩张、充血、出血,炎症细胞浸润,可有胆汁淤积。病程数天后坏死灶周围出现胆

Coagulation abnormalities, bleeding, thrombosis, and management of patients with acute liver failure in Australia and New Zealand复制标题

澳大利亚和新西兰急性肝衰竭患者的凝血功能障碍、出血、血栓形成和管理

发表时间:2019-11-05

影响因子:3.6

作者: Stephen Warrillow

期刊:J Gastroenterol Hepatol

Key findings. In patients with severe ALF admitted to liver transplant ICUs in ANZ, we found that INR appeared to dominate coagulation monitoring and treatment; however, its association with bleeding was not significant. Low platelet counts and low fibrinogen concentrations were significantly associated with bleeding; however, fibrinogen monitoring was significantly less frequent. Clotting factor use and blood product administration were common. However, unlike for other products, which differed in use according to clear derangements, the initial use of FFP did not. Bleeding occurred in less than a fifth of patients while thrombotic complications occurred in less than 10% and half occurred many days after ELT.The dominant approach to hematological monitoring in centration and platelet count seems more relevant to the risk of and bleeding appears novel14,16–24 (Table S5).

译文

主要发现。 在ANZ接受肝移植ICU的重度ALF患者中,我们发现INR似乎在凝血监测和治疗中占主导地位。 然而,其与出血的关联并不显着。 低血小板计数和低纤维蛋白原浓度与出血密切相关。 然而,纤维蛋白原监测的频率明显降低。 凝血因子的使用和血液制品的给药很常见。 但是,与其他产品不同,它们的使用因明显的变化而有所不同,而FFP的初始使用没有变化。 在ELT发生后的不到五分之一患者发生出血,而发生血栓性并发症的发生率不到10%,一半发生在血液中。占主导地位的血液学监测血液中浓度和血小板计数似乎与发生新血栓的风险更相关14,16 –24(表S5)。