摘要

OBJECTIVE:There are currently no definitive disease-modifying therapies for traumatic brain injury (TBI). In this study, we present a strong therapeutic candidate for TBI, immunomodulatory nanoparticles (IMPs), which ablate a specific subset of hematogenous monocytes (hMos). We hypothesized that prevention of infiltration of these cells into brain acutely after TBI would attenuate secondary damage and preserve anatomic and neurologic function.
METHODS:IMPs, composed of US Food and Drug Administration-approved 500nm carboxylated-poly(lactic-co-glycolic) acid, were infused intravenously into wild-type C57BL/6 mice following 2 different models of experimental TBI, controlled cortical impact (CCI), and closed head injury (CHI).
RESULTS:IMP administration resulted in remarkable preservation of both tissue and neurological function in both CCI and CHI TBI models in mice. After acute treatment, there was a reduction in the number of immune cells infiltrating into the brain, mitigation of the inflammatory status of the infiltrating cells, improved electrophysiologic visual function, improved long-term motor behavior, reduced edema formation as assessed by magnetic resonance imaging, and reduced lesion volumes on anatomic examination.
INTERPRETATION:Our findings suggest that IMPs are a clinically translatable acute intervention for TBI with a well-defined mechanism of action and beneficial anatomic and physiologic preservation and recovery. Ann Neurol 2020;87:442-455.

译文

目的: 目前没有明确的创伤性脑损伤 (TBI) 的疾病改善疗法。在这项研究中,我们提出了一个强有力的 TBI 治疗候选,免疫调节纳米颗粒 (IMPs),它消融血行单核细胞 (hMos) 的特定子集。我们假设,在 TBI 后,防止这些细胞急性渗入大脑将减轻继发性损伤,并保持解剖和神经功能。
方法: IMPs,由美国食品和药物管理局批准的 500nm 羧化聚 (乳酸-乙醇酸) 酸组成, 在 2 种不同的实验性 TBI 、控制性皮质撞击 (CCI) 和闭合性头部损伤 (CHI) 模型后,静脉注射到野生型 C57BL/6 小鼠体内。
结果: 在 CCI 和 CHI TBI 小鼠模型中,IMP 给药显著保留了组织和神经功能。急性治疗后,渗入大脑的免疫细胞数量减少,浸润细胞炎症状态减轻,电生理视觉功能改善, 通过磁共振成像评估,改善了长期运动行为,减少了水肿形成,并在解剖学检查中减少了病变体积。
解释: 我们的研究结果表明,IMPs 是一种临床上可翻译的 TBI 急性干预措施,其作用机制明确,并具有有益的解剖和生理保护和恢复。Ann Neurol 2020; 87: 442-455。

traumatic brain injury

重症 脑损伤 疾病
概述  :  

创伤性颅脑损伤(traumatic brain injury , TBI)已成为发达国家青少年伤病致死的首位病因。随着国民经济和交通等的发展,我国颅脑伤的发生率和因颅脑伤致残、致死的伤员也逐年增加。虽然TBI的总体死亡率由30年前的50%降低至目前的30%左右,但是存活的患者中,轻度损伤患者10%会遗留永久残疾,而中度和重度患者可达到66%和100%。 病理机制1、以小鼠模型进行相关研究:①病理检查可见神经元细胞核、尼氏体和细胞器出现不同程度的损伤及缺血性改变;②脑含水量测定提示存

traumatic 英 [ trɔ:ˈmætɪk ] 美 [ trəˈmætɪk ]

释义   adj. (心理)创伤的;adj. (生理)外伤的

例句   The first time this kind of thing happened it was upsetting but not traumatic, and he would have recovered from it with no problem.第一次发生这样的事情让人心烦,但不是创伤性的,他本来可以毫无问题地康复的。

 

Injury 英 [ ˈɪndʒəri ] 美 [ ˈɪndʒəri ]

释义   n. 伤害,损害;受伤处

例句   If my presence is an injury to someone, how can I do ?如果我的出现是对某人的伤害,我该怎么办?


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