摘要

Chiral sonochemical hydrogenation of an aliphatic alpha-ketoester, ethyl pyruvate to ethyl lactate was carried out over various platinum catalysts in different solvents under atmospheric hydrogen pressure. The reaction rates and the enantiomeric excesses were determined over Pt/C, Pt/SiO2 and Pt/K-10 catalysts both under conventional and sonochemical conditions. The effect of ultrasounds on the catalytic activity and enantioselectivity was tested applying sonochemical pretreatment before the reaction. The ultrasonic irradiation was found to be highly advantageous in these hydrogenations. After insonation of the catalysts, the enantioselectivity was highly improved over Pt/SiO2 and Pt/K-10 catalysts. In addition, the reactions took place in quantitative yield and with complete chemoselectivity and the hydrogenation rates increased with one order of magnitude despite the very mild (atmospheric hydrogen pressure, room temperature) experimental conditions.

译文

在大气压氢气压力下,在不同的溶剂中,在不同的铂催化剂上对脂肪族 α-酮酸酯、丙酮酸乙酯进行了手性声化学氢化。在常规和声化学条件下,在 Pt/C 、 Pt/SiO2 和 Pt/K-10 催化剂上测定了反应速率和对映体过量。反应前应用声化学预处理测试了超声波对催化活性和对映体选择性的影响。发现超声波辐射在这些氢化反应中非常有利。催化剂分离后,Pt/SiO2 和 Pt/K-10 催化剂对映体选择性大大提高。此外,反应以定量产率发生,并具有完全的化学选择性,并且尽管在非常温和的 (大气氢压力,室温) 实验条件下,氢化速率以一个数量级的速度增加。

Ethyl pyruvate

重症 脓毒症 药物
概述  :  

丙酮酸乙酯(Ethyl Pyruvate, EP)分子式:C5H8O3,分子量:116.12,一种稳定性高、亲脂性强的丙酮酸脂化物,作为丙酮酸的替代物广泛应用于动物实验。是一种有效的HMGB1抑制剂,具有抗炎和免疫调节效应。已有研究表明EP能降低致死性脓毒症小鼠的死亡率和有效改善重症急性胰腺炎的症状,具有一定的器官保护作用。 作用机制丙酮酸乙酯是一种重要的医药中间体,在医药、农药、食品、化妆品等领域有广泛的用途,目前尚未广泛临床应用,存在于基础研究及动物实验中,本次就其对脓毒症治疗

Ethyl 英 [ ˈeθɪl;ˈiːθaɪl ] 美 [ ˈeθɪl,ˈiːθaɪl ]   

释义   n. 乙烷基;含四乙铅的汽车燃料

例句   Other ingredients:Gelatin, Glycerin, Soybean Oil, White Thyme Oil, Clove Oil and Ethyl Vanillin.其他成分:明胶,甘油,大豆油,白百里香油,丁香油和乙基香兰素。

 

pyruvate 英 [ paɪ'ru:veɪt] 美 [ pɪ'rʊvet ]   

释义   n. [有化] 丙酮酸盐;丙酮酸酯

例句   These two amino acids derive their carbon skeletons from pyruvate.这两种氨基酸的碳骨架来源于丙酮酸。


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