摘要

BACKGROUND:Markedly activated neutrophils or higher plasma levels of neutrophil elastase are involved in the poor response to intravenous immunoglobulin (IVIG) and the formation of coronary artery lesions (CAL) in patients with acute Kawasaki disease. We hypothesized that ulinastatin (UTI), by both direct and indirect suppression of neutrophils, would reduce the occurrence of CAL.
METHODS AND RESULTS:We retrospectively analyzed the clinical records of patients with Kawasaki disease between 1998 and 2009. Three hundred sixty-nine patients were treated with a combination of UTI, aspirin, and IVIG as an initial treatment (UTI group), and 1178 were treated with a conventional initial treatment, and IVIG with aspirin (control group). The baseline characteristics did not demonstrate notable differences between the two groups. The occurrence of CAL was significantly lower in the UTI group than in the control group (3% versus 7%; crude odds ratio [OR], 0.46; 95% confidence interval [CI], 0.25-0.86; P=0.01). The OR adjusted for sex, Gunma score (the predictive score for IVIG unresponsiveness), and dosage of initial IVIG (1 or 2 g/kg) was 0.32 (95% CI, 0.17-0.60; P

译文

背景: 明显活化的中性粒细胞或较高的血浆中性粒细胞弹性蛋白酶水平与静脉注射免疫球蛋白 (IVIG) 反应不佳和冠状动脉病变 (CAL) 的形成有关。急性川崎病患者。我们假设乌司他丁 (UTI) 通过直接和间接抑制中性粒细胞,将减少 CAL 的发生。
方法和结果: 我们回顾性分析了 1998年至 2009 间川崎病患者的临床记录。300 69 名患者接受了 UTI 、阿司匹林和 IVIG 的联合治疗作为初始治疗 (UTI 组),1178 名患者接受了常规初始治疗, 和 IVIG 加阿司匹林 (对照组)。基线特征没有显示出两组之间的显著差异。UTI 组的 CAL 发生率明显低于对照组 (3% 对 7%; 粗略比值比 [OR],0.46; 95% 置信区间 [CI], 0.25-0.86; P = 0.01)。根据性别、 Gunma 评分 (IVIG 无反应的预测评分) 和初始 IVIG 剂量 (1 或 2 g/kg) 调整的 OR 为 0.32 (95% CI,0.17-0.60; P

Ulinastatin

重症 急性胰腺炎 药物
概述  :  

1909年,Beuer和Reich首次报道了尿液中存在蛋白酶抑制剂(ulinary trypsin inhibitor ,UTI),现多称为乌司他丁(ulinastatin),能有效抑制多种酶的活性。后来研究发现,在感染、肿瘤、妊娠、休克、手术,给予糖皮质激素等生物体受到刺激时,尿液中该物质活性升高。大量的临床试验结果显示乌司他丁治疗急性胰腺炎、辅助治疗休克、改善手术预后尤其是减少体外循环并发症等方面有重要的作用,加上其本身来源于人体,无免疫原性,安全性高。乌司他丁是从男性尿中分离纯化的尿胰

ulinastatin 

释义   乌司他丁

例句   Conclusion Ulinastatin can effectively enhance the immunity function of the patients undergoing HIFU treatment for liver cancer.

结论乌司他丁可有效增强HIFU治疗肝癌患者的免疫功能。


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