例句 A new drug was found, daptomycin, to treat infective endocarditis.
作者： Kaye KS
期刊：Antimicrob. Agents Chemother.
Although bloodstream infections (BSI) due to methicillin-resistant Staphylococcus aureus (MRSA) remain a common health care problem worldwide, clinical failure rates using guideline-concordant treatment, including vancomycin or daptomycin monotherapy, remain unacceptably high, approaching 20 to 30% in many studies，Furthermore, rates of complications including metastatic disease such as endocarditis and vertebral osteomyelitis, are extraordinarily high. Thus, innovative approaches to treatment are needed. Geriak et al. sought to determine the impact of early initiation of combination therapy (with daptomycin and ceftaroline) on clinical outcomes in patients with MRSA BSI. This was an important, albeit small, nonblinded clinical trial that demonstrated decreased mortality among patients who received daptomycin and ceftaroline compared to the standard of care (i.e., monotherapy with either vancomycin or daptomycin) . There are several limitations to the study some of which the authors recognize, including the small sample size, disproportionate randomization, the open-label nature of the trial, and the lack of a data safety monitoring board (DSMB). Despite this, the study findings are extremely important and demonstrate the need for an adequately powered, well-controlled clinical trial comparing the two treatment arms.