摘要

Cold agglutinin disease (CAD) is a rare condition leading to blood agglutination at cold temperatures and auto- immune hemolytic anemia. The incidence of CAD is 1/ 1,000,000 people per year, and the disease accounts for 13–15% of auto-immune hemolytic anemias. Clinical manifestations can occur in colder weather and the pathologic antibodies can bind to RBC cells and cause agglutination at areas of lower body temperature (including extremities). Cutaneous manifestations of CAD include acrocyanosis and Raynaud’s phenomenon. Head and neck manifestations are uncommon. Cutaneous ischemia resulting from CAD acrocyanosis in the head and neck is uncommon, with tissue loss resulting in potential disfigurement. Management and outcomes are variable, often with subsequent tissue loss (Table 1). Treatment regimens can include targeting underlying immune response, anticoagulants, and surgical debridement. We describe the successful management of this condition with vasodilators and hyperbaric oxygen therapy.

译文

冷凝集素病(CAD)是一种罕见病,会导致在低温下发生血液凝集和自身免疫性溶血性贫血。每年CAD的发生率为1 / 1,000,000人,该疾病占自身免疫性溶血性贫血的13–15%。临床表现可发生在寒冷的天气中,病理抗体可与RBC细胞结合并在较低体温的区域(包括四肢)引起凝集。 CAD的皮肤表现包括肢端发cyan和雷诺现象。头颈部表现不常见。头部和颈部的CAD肢端氰化病引起的皮肤局部缺血并不常见,组织损失导致潜在的毁容。管理和结果是可变的,通常伴随随后的组织损失(表1)。治疗方案可包括针对潜在的免疫反应,抗凝剂和外科清创术。我们描述了通过血管扩张药和高压氧疗法对这种疾病的成功管理。

Hyperbaric oxygen

重症 输氧 治疗方法
概述  :  

高压氧(hyperbaric oxygen , HBO)定义就其高压氧医学几本权威的教科书和参考书有如下3种:(1)机体处于高气压环境中所呼吸的与环境等压的纯氧称高压氧;(2)人们把超过1个大气压的压力称高气压,在高气压环境中呼吸氧气称高压氧;(3)凡是气体压力超过1个大气压时叫做高气压,在高气压环境下吸纯氧称高压氧。高压氧与常压氧不仅有量的不同,更重要的是有质的差异,其不同点有:(1)高压氧可增加血及组织中的物理溶解氧,实现无血生命,即将动物体内红细胞去掉,在高压氧下,动物的生命平稳,但常

Hyperbaric 英 [ haɪpəˈbærɪk ] 美 [ haɪpərˈbærɪk ]   

释义   adj. 高气压的;施压力以供氧气的

例句   Objective To discuss the effect of hyperbaric oxygen(HBO) therapy on the daily living activity and depression after craniocerebral injury. 

目的探讨高压氧治疗对颅脑损伤患者日常生活活动及抑郁的影响。


请扫描右侧二维码,免费查看词汇专业知识背景