摘要

Heat stroke is a life-threatening condition clinically diagnosed as a severe elevation in body temperature with central nervous system dysfunction that often includes combativeness, delirium, seizures, and coma. Classic heat stroke primarily occurs in immunocompromised individuals during annual heat waves. Exertional heat stroke is observed in young fit individuals performing strenuous physical activity in hot or temperature environments. Long-term consequences of heat stroke are thought to be due to a systemic inflammatory response syndrome. This article provides a comprehensive review of recent advances in the identification of risk factors that predispose to heat stroke, the role of endotoxin and cytokines in mediation of multi-organ damage, the incidence of hypothermia and fever during heat stroke recovery, clinical biomarkers of organ damage severity, and protective cooling strategies. Risk factors include environmental factors, medications, drug use, compromised health status, and genetic conditions. The role of endotoxin and cytokines is discussed in the framework of research conducted over 30 years ago that requires reassessment to more clearly identify the role of these factors in the systemic inflammatory response syndrome. We challenge the notion that hypothalamic damage is responsible for thermoregulatory disturbances during heat stroke recovery and highlight recent advances in our understanding of the regulated nature of these responses. The need for more sensitive clinical biomarkers of organ damage is examined. Conventional and emerging cooling methods are discussed with reference to protection against peripheral organ damage and selective brain cooling.

译文

中暑是一种危及生命的疾病,临床诊断为体温严重升高,伴有中枢神经系统功能障碍,通常包括好斗、谵妄、癫痫发作和昏迷。典型的中暑主要发生在免疫功能低下的个体每年的热浪中。在炎热或高温环境中进行剧烈体育活动的年轻健康个体中观察到劳力性中暑。中暑的长期后果被认为是由于全身炎症反应综合征。这篇文章提供了一个全面的综述,综述了在识别容易发生中暑的危险因素、内毒素和细胞因子在调解多器官损伤中的作用方面的最新进展。中暑恢复期间低体温和发热的发生率、器官损伤严重程度的临床生物标志物以及保护性降温策略。风险因素包括环境因素、药物使用、健康状况受损和遗传状况。内毒素和细胞因子的作用在 30 多年前进行的研究框架中讨论,需要重新评估以更清楚地确定这些因素在全身炎症反应综合征中的作用。我们质疑下丘脑损伤是中暑恢复过程中体温调节紊乱的原因,并强调我们对这些反应的调节性质的理解的最新进展。研究需要更敏感的器官损伤临床生物标志物。传统的和新兴的冷却方法是参照保护周围器官损伤和选择性脑冷却来讨论的。

heat stroke

重症 中暑 疾病
概述  :  

热射病(heat stroke , HS)为致命性中暑,是一种全身炎症性反应综合征(SIRS),主要临床表现为核心体温在(40℃-47℃)、皮肤干热及中枢神经系统异常,如注意力不集中、记忆减退、谵妄、惊厥、昏迷等,重症患者可出现多器官功能障碍综合征(MODS)。一般可将其分为两类:非劳力性热射病(classic/nonexertional heat stroke , CHS)和劳力性热射病(exertional heat stroke , EHS)。CHS由暴露

Heat 英 [hiːt] 美 [hiːt]  

释义   n. 高温;压力;热度;热烈

vt. 使激动;把…加热 复数 heats 过去式 heated

例句   No heat can pass through it to the outside.  

没有热量可以通过它向外泄漏。

 

Stroke 英 [strəʊk] 美 [stroʊk]  

释义   n. 中风;打击;笔画;冲程;尝试;轻抚

vt. 抚摸;敲击;划尾桨;划掉;

vi. 击球;作尾桨手,敲击键盘

例句   However, there was no association with total stroke.

然而,与卒中总数并不存在联系。


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