摘要

42 subfertile patients with normal levels of plasma testerone (26 subnormal, suffering from oligospermia) have been treated with a combination of clomiphene citrate (50 mg Clomid daily) and mesterolon (50 mg Proviron daily) over a period of at least 3-6 months. The treatment resulted in pregnancy in 6 cases and in a significant improvement of the sperm count in 16. In 7, however, whilst the sperm count improved the qualitative results were unsatisfactory as many sperms were immature. Restricted spermatogenesis and a sperm count below 5 million/ml must be considered unfavourable but does not constitute a counter-indication to the combined therapy. No hazardous complications were observed.

译文

42 名血浆孕酮水平正常的亚育患者 (26 名亚正常，患有少精症) 已经接受了克罗米芬 (每天 50 mg Clomid) 和麦斯托隆 (每天 50 mg Proviron) 的联合治疗在至少 3-6 个月的时间里。治疗导致 6 例妊娠，16 例精子数量显著改善。然而，在 7 年，虽然精子数量有所提高，但由于许多精子不成熟，定性结果并不令人满意。限制精子发生和精子数量低于 500万个/毫升必须被认为是不利的，但不构成联合疗法的相反指征。未观察到危险的并发症。