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clomiphene citrate

妇产

关键词妇产 药物 促排卵

词汇介绍

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解析

clomiphene  英 ['klɒməfi:n] 美 ['kloʊməfin]

释    义   n. 克罗米酚,舒经酚(一种合成的助生育药)

例    句   The most commonly prescribed ovulation drug is clomiphene citrate ( CC ). 最常用的排卵药是克罗米酚 ( CC )。

 

citrate  英 ['sɪtreɪt] 美 ['sɪtreɪt]

释    义   n. 柠檬酸盐

例    句   Levels of serum estradiol and progesterone were statistically significantly higher in the clomiphene citrate group. 在克罗米芬治疗组,血清雌激素和孕酮的水平明显升高。

概述

社会的快速发展,导致诸如水、食物、空气等质量受到影响,越来越多的人开始患上不孕不育症。不孕不育症情况复杂,有些是因为男性的原因,有些则是因为女性的原因。治疗不孕不育症需要根据病情来决定,药物是重要的解决手段,氯米芬具有较强的抗雌激素作用和较弱的雌激素活性临床上主要用于避孕药引起的闭经及月经紊乱,是解决排卵的女性不育症中经常用到的药物。 适应证与禁忌证使用氯米芬的适应症为1)治疗无排卵的女性不育症,适用于体内有一定雌激素水平者;2)治疗黄体功能不足;3)测试卵巢功能;4)探测男性下丘

Letrozole Compared With Clomiphene Citrate for Unexplained Infertility A Systematic Review and Meta-analysis.复制标题

来曲唑与枸橼酸氯米芬治疗不明原因不孕症的比较: 系统回顾和荟萃分析。

发表时间:2019-03-10

影响因子:5.0

作者: Ashley M. Eskew

期刊:Obstet Gynecol

Oral ovarian stimulation agents such as clomiphene citrate, a selective estrogen receptor modulator, and letrozole, an aromatase inhibitor, are effective, have fewer adverse side effects, and lower cost than injectable gonadotropins. After a basic infertility workup, oral ovulation induction is often the first step in treatment before referral to reproductive endocrinology. Clomiphene citrate is the standard first line agent for ovarian stimulation. However, studies have shown that clomiphene citrate may alter surrogate parameters of uterine receptivity and cervical mucus, which may explain why pregnancy rates are often lower than expected from observed ovulation rates. Letrozole lacks the antiestrogenic effects of clomiphene citrate on the endometrium and has a shorter half-life, contributing to reduced side effects. Additionally, use of aromatase inhibitors appears to improve endometrial thickness compared to clomiphene citrate and may be less likely to result in multiple gestations. Letrozole use also resulted in higher live birth rates compared to clomiphene citrate in patients with PCOS.

译文

口服卵巢刺激剂,如选择性雌激素受体调节剂克罗米芬和芳香化酶抑制剂来曲唑,比注射性促性腺激素有效,副作用少,成本低。在基本的不孕症检查之后,在转诊生殖内分泌科之前,口服促排卵通常是治疗的第一步。枸橼酸氯米芬是刺激卵巢的标准一线药物。然而,研究表明,枸橼酸氯米芬可能改变子宫容受性和宫颈粘液的替代参数,这可能解释为什么从观察到的排卵率来看,妊娠率往往低于预期。来曲唑缺乏克罗米酚对子宫内膜的抗雌激素作用,半衰期较短,有助于减少副作用。此外,芳香化酶抑制剂的使用似乎比克罗米酚柠檬酸盐改善子宫内膜厚度,可能不太可能导致多胎妊娠。来曲唑的使用也导致多囊卵巢综合征患者的活产率高于克罗米芬。