释 义 adj. [解剖] 子宫内膜的
同根词 词根： endometrium
n.endometriosis [妇产] 子宫内膜异位 endometrium [解剖] 子宫内膜
例 句 However, the use of hormone therapy can increase the risk of blood clots, endometrial cancer and, possibly, breast cancer. 但使用激素疗法会增加血凝块、子宫内膜癌风险，它也可能会增加乳腺癌的风险。
hyperplasia 英 [,haɪpə'pleɪzɪə] 美 [,haɪpɚ'pleʒə]
释 义 n. [病理] 增生；畸形生长
例 句 Cancer cell why can infinite hyperplasia? 癌细胞为什么能无限增殖?
作者： Jumpei Terakawa
期刊：Proc. Natl. Acad. Sci. U.S.A.
Endometrioid endometrial carcinomas (EECs) carry multiple driver mutations even when they are low grade. However, the biological significance of these concurrent mutations is unknown. We explored the interactions among three signature EEC mutations: loss-of-function (LOF) mutations in , gain-of-function (GOF) mutations of phosphoinositide 3-kinase (PI3K), and exon 3 mutations, utilizing in vivo mutagenesis of the mouse uterine epithelium. While epithelial cells with a monoallelic mutation in any one of three genes failed to propagate in the endometrium, any combination of two or more mutant alleles promoted the growth of epithelium, causing simple hyperplasia, in a dose-dependent manner. Notably, exon 3 deletion significantly increased the size of hyperplastic lesions by promoting the growth of PTEN LOF and/or PI3K GOF mutant cells through the activation of neoadenogenesis pathways. Although these three mutations were insufficient to cause EEC in intact female mice, castration triggered malignant transformation, leading to myometrial invasion and serosal metastasis.