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Recurrent spontaneous abortion

妇产

关键词妇产 疾病 妊娠并发症

词汇介绍

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解析

recurrent [rɪ'kʌr(ə)nt]  [rɪ'kɝənt]

       adj. 复发的;周期性的,经常发生的

同根词   词根: recur

adj.recurring 循环的;再发的  adv.recurrently 循环地(周而复始地)

       It is the primary cause of recurrent ear infections in children. 它也是造成孩子周期性耳朵感染的主要原因。

 

spontaneous [spɒn'teɪnɪəs]  [spɑn'tenɪəs]

       adj. 自发的;自然的;无意识的

       That tells us whether the change is spontaneous. 这可以告诉我们变化是否是自发的。

 

abortion [ə'bɔːʃ(ə)n]  [ə'bɔrʃən]

       n. 流产,堕胎

同根词   词根: abort

adj. abortive 失败的;流产的;堕胎的

adv. abortively 失败地;流产地

n. abort 中止计划

       They are discussing the morality of abortion. 他们正在讨论堕胎的道德性

概述

 复发性流产(recurrent spontaneous abortion, RSA)一般指与同一配偶发生连续3次或3次以上的自然流产。近年来许多学者提出将连续发生2次的自然流产者纳入RSA的范畴,原因是连续发生2次自然流产后,再次妊娠的流产率可高达50%以上,要引起足够的重视。 常见病因 1. 子宫因素:引起复发性流产的子宫解剖结构异常主要包括子宫肌瘤、子宫粘膜下息肉、各种子宫先天性畸形,另外宫腔粘连、子宫颈机能不全也是引起复发性流产的原因。解剖因素

Immunological Basis for Recurrent Fetal Loss and Pregnancy Complications复制标题

复发性胎儿损失和妊娠并发症的免疫学基础

发表时间:2019-01-24

影响因子:13.8

作者: Hitesh Deshmukh

期刊:Annu Rev Pathol

Pregnancy stimulates an elaborate assortment of dynamic changes, allowing intimate approximation of genetically discordant maternal and fetal tissues. Although the cellular and molecular details about how this works remain largely undefined, important clues arise from evaluating how a prior pregnancy influences the outcome of a future pregnancy. The risk of complications is consistently increased when complications occurred in a prior pregnancy. Reciprocally, a prior successful pregnancy protects against complications in a future pregnancy. Here, we summarize immunological perturbations associated with fetal loss, with particular focus on how both harmful and protective adaptations may persist in mothers. Immunological aberrancy as a root cause of pregnancy complications is also considered, given their shared overlapping risk factors and the sustained requirement for averting maternal-fetal conflict throughout pregnancy. Understanding pregnancy-induced immunological changes may expose not only new therapeutic strategies for improving pregnancy outcomes but also new facets of how immune tolerance works that may be applicable to other physiological and pathological contexts.

译文

怀孕刺激了精细的各种动态变化,允许对遗传不一致的母体和胎儿组织进行近似的近似。尽管关于其如何起作用的细胞和分子细节仍未明确定义,但评估先前妊娠如何影响未来妊娠结果的重要线索。在先前的妊娠中发生并发症时,并发症的风险一直在增加。相反,先前成功的妊娠可以预防未来怀孕期间的并发症。在这里,我们总结了与胎儿丢失相关的免疫扰动,特别关注有害和保护适应可能如何在母亲中持续存在。鉴于其共有的重叠危险因素以及在整个妊娠期间避免母胎冲突的持续需求,还考虑了免疫异常作为妊娠并发症的根本原因。了解妊娠引起的免疫学变化可能不仅暴露了改善妊娠结局的新治疗策略,而且还揭示了免疫耐受如何起作用的新方面,可能适用于其他生理和病理环境。