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maternal-fetal interface

妇产

关键词妇产 基础研究专业名词类 胎儿附属物形成与功能

词汇介绍

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解析

maternal [mə'tɜ:n(ə)l]  [mə'tɝnl]

       adj. 母亲的;母性的;母系的;母体遗传的

       You will notice I am not addressing the paternal side of this issue only the maternal. 你会注意到在这个问题上我不是站在父亲这边,而是站在母亲这边。

 

fetal ['fi:t(ə)l]  ['fitl]

       adj. 胎的,胎儿的

同根词    词根:fetal

n.feticide 堕胎,杀害胎儿

       This is because during this period of slow fetal growth. 这是因为这一时期胎儿生长的较慢。

 

interface ['ɪntəfeɪs]  ['ɪntɚ'fes]

       n. 界面;<>接口;交界面

       It should be independent, it should not have any association with user interface issues. 它应该是独立的,不应该与用户界面问题有任何关联。

概述

 母胎界面是指妊娠过程中的子宫内膜和胚外组织部分,是母体与胎儿直接“对话”接触的界面,主要包括壁蜕膜、底蜕膜、绒毛或滋养层。而这些结构主要由滋养层细胞、蜕膜细胞及免疫细胞构成。任何导致母胎界面微环境改变的因素都有可能导致不良妊娠结局的发生。 早产与母胎界面的关系 1. 滋养层细胞与早产:滋养层细胞由滋养外胚层发育而来,从细胞类型上可以将滋养层细胞分为两大类:细胞滋养层细胞(cytotrophoblasts,CTBs)和合胞体滋养层细胞(syncytio

Single-cell reconstruction of the early maternal-fetal interface in humans.复制标题

人类早期母胎界面的单细胞重建。

发表时间:2018-11-14

影响因子:43.1

作者: Roser Vento-Tormo

期刊:Nature

During early human pregnancy the uterine mucosa transforms into the decidua, into which the fetal placenta implants and where placental trophoblast cells intermingle and communicate with maternal cells. Trophoblast-decidual interactions underlie common diseases of pregnancy, including pre-eclampsia and stillbirth. Here we profile the transcriptomes of about 70,000 single cells from first-trimester placentas with matched maternal blood and decidual cells. The cellular composition of human decidua reveals subsets of perivascular and stromal cells that are located in distinct decidual layers. There are three major subsets of decidual natural killer cells that have distinctive immunomodulatory and chemokine profiles. We develop a repository of ligand-receptor complexes and a statistical tool to predict the cell-type specificity of cell-cell communication via these molecular interactions. Our data identify many regulatory interactions that prevent harmful innate or adaptive immune responses in this environment. Our single-cell atlas of the maternal-fetal interface reveals the cellular organization of the decidua and placenta, and the interactions that are critical for placentation and reproductive success.

译文

在人类怀孕早期,子宫粘膜转变为蜕膜,胎儿胎盘植入蜕膜,胎盘滋养层细胞混合并与母体细胞交流。滋养层 - 蜕膜相互作用是妊娠常见疾病的基础,包括先兆子痫和死胎。在这里,我们分析了来自妊娠早期胎盘的约70,000个单细胞的转录组,其具有匹配的母体血液和蜕膜细胞。人蜕膜的细胞组成揭示了位于不同蜕膜层的血管周围和基质细胞的亚群。蜕膜自然杀伤细胞有三个主要子集,具有独特的免疫调节和趋化因子谱。我们开发了配体 - 受体复合物的储存库和统计工具,以通过这些分子相互作用预测细胞 - 细胞通讯的细胞类型特异性。我们的数据识别许多调节相互作用,以防止在这种环境中有害的先天或适应性免疫反应我们的母胎界面单细胞图谱揭示了蜕膜和胎盘的细胞组织,以及对胎盘和繁殖成功至关重要的相互作用。