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endometrial carcinoma

妇产

关键词妇产 疾病 子宫内膜癌

词汇介绍

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解析

endometrial    [ɛndʌ'mɛtrɪəl]

释    义   adj. [解剖] 子宫内膜的

同根词   endometrium

n. endometriosis [妇产] 子宫内膜异位症 endometrium [解剖] 子宫内

endometritis [妇产] 子宫内膜炎

例    句   However, the use of hormone therapy can increase the risk of blood clots, endometrial cancer and, possibly, breast cancer. 但使用激素疗法会增加血凝块、子宫内膜癌风险,它也可能会增加乳腺癌的风险。

 

carcinoma    英 [kɑːsɪ'nəʊmə]  美 [kɑrsɪ'nomə]

释    义   n. [肿瘤] 癌

同根词   Objective To study the correlation between expression of CD105 and lymph node metastasis in thyroid carcinoma tissue. 目的研究甲状腺癌组织中CD105的表达意义及与淋巴结转移的相关性。

概述

目前根据临床、内分泌学和组织病理学特征将子宫内膜癌分为两种类型:型 (子宫内膜样) 和Ⅱ型 (非子宫内膜样) 子宫内膜癌。两种类型的子宫内膜癌不仅表型和分子机制不同,其生物学行为也大相径庭。Ⅰ型子宫内膜癌,即子宫内膜样癌,占内膜癌的70%~80%,其发病通常与雌激素刺激有关,常伴随子宫内膜异常增生;免疫组化显示雌激素受体和孕激素受体高表达。临床诊断大部分为早期患者,即使为晚期经过手术和放化疗等治疗后,部分患者预后仍然较好。10%~20%的子宫内膜癌为Ⅱ型内膜癌,肿瘤发展与雌激素刺激无关,多发

Molecular classification of endometrial carcinoma applied to endometrial biopsy specimens: Towards early personalized patient management.复制标题

子宫内膜癌应用于子宫内膜活检标本的分子分类: 走向早期个性化患者管理。

发表时间:2019-06-19

影响因子:4.4

作者: Abdulfatah E

期刊:Gynecol. Oncol

Endometrial carcinoma is the most common gynecological malignancy in the United States . Stratification of patients with endometrial carcinoma into several risk groups is currently based on post surgical pathological information including histologic subtype, tumor grade, stage, lymphovascular and myometrial invasion.However, high-grade endometrial carcinomas cannot be reliably classified by histomorphologic criteria with moderate to poor inter-observer agreement for histotype and tumor grade. In addition, 8–10% of early stage endometrial carcinomas develop recurrence and distant metastasis, hence the need for more reliable systems to categorize and classify endometrial carcinomas to inform clinical management. Using a combination of whole exome and whole genome sequencing and copy number analysis, The Cancer Genome Atlas (TCGA) classified endometrial carcinomas into four prognostically distinct molecular subtypes: POLE ultramutated, hypermutated with microsatellite instability (MSI), copy number-low and copy number-high subtypes. Molecular classification of endometrial carcinoma has shown great promise, proving to be reproducible, demonstrating associations with clinical outcomes and providing valuable prognostic and predictive information.

译文

子宫内膜癌是美国最常见的妇科恶性肿瘤。将子宫内膜癌患者分为几个风险组目前是基于手术后病理信息,包括组织学亚型,肿瘤分级,分期,淋巴血管和子宫肌层浸润。然而,高级别子宫内膜癌不能通过组织形态学标准可靠地分类为中度至差观察员间对组织型和肿瘤分级的一致意见。此外,8-10%的早期子宫内膜癌发生复发和远处转移,因此需要更可靠的系统进行分类和分类子宫内膜癌告知临床管理。使用整个外显子组和全基因组测序和拷贝数分析的组合,癌症基因组图谱(TCGA)将子宫内膜癌分为四种预后不同的分子亚型:POLE超突变,超微突变,微卫星不稳定性(MSI),拷贝数低和拷贝数 - 高亚型。子宫内膜癌的分子分类显示出巨大的希望,证明是可重复的,证明与临床结果相关并提供有价值的预后和预测信息。