摘要

The prognosis and therapy for dysgerminomas are different from those of other ovarian tumor types, making accurate diagnosis imperative for patient care. OCT4 (POU5F1) is a transcription factor involved in the regulation of pluripotency during embryonic development. It can be detected in both pluripotent cells and other early germ cells. This study examines the expression of OCT4 in both dysgerminoma and nondysgerminomatous neoplasms involving the ovary. Formalin-fixed, paraffin-embedded cell blocks of 33 cases of dysgerminoma including 2 cases of gonadoblastoma associated with dysgerminoma and 3 cases of metastatic dysgerminoma, and 111 cases of nondysgerminomatous neoplasms involving the ovary were stained using the antibody against OCT4. All cases of dysgerminomas and gonadoblastomas were positive for OCT4 with strong nuclear staining. More than 90% of dysgerminoma cells in each case showed diffuse strong nuclear staining. In addition, 3 metastatic dysgerminomas also showed uniform strong nuclear staining. All nondysgerminomatous tumors (mature teratoma, 14; yolk sac tumor, 4; Sertoli-Leydig cell tumor, 15; granulosa cell tumor, 22; Brenner tumor, 3; carcinoid tumor, 4; struma ovarii, 2; fibroma, 5; thecoma, 1; serous adenocarcinoma, 5; endometrioid adenocarcinoma, 4; small cell carcinoma, 6; stromal sarcoma, 1; malignant lymphoma, 6; metastatic malignant melanoma, 1; metastatic carcinoid, 2; metastatic small cell carcinoma, 1; and metastatic lobular carcinoma of the breast, 1) were negative for OCT4, except for some cases of clear cell adenocarcinoma of the ovary. Four of 14 clear cell adenocarcinomas showed focal positive nuclear immunoreactivity for OCT4. OCT4 is a sensitive and relatively specific biomarker for the detection of dysgerminoma. It may also be useful in the diagnosis of gonadoblastoma, which contains similar cells and may be associated with dysgerminoma. OCT4 may aid in the detection of small foci of metastatic dygerminoma in extraovarian sites and may also help distinguish dysgerminoma from other primary and metastatic tumors of the ovary.

译文

发育不良瘤的预后和治疗不同于其他类型的卵巢肿瘤,因此准确的诊断对患者护理至关重要。OCT4 (POU5F1) 是一种转录因子,参与胚胎发育过程中多能性的调节。它可以在多能细胞和其他早期生殖细胞中检测到。这项研究检测了 OCT4 在涉及卵巢的无性细胞瘤和非无性肿瘤中的表达。33 例无性细胞瘤的福尔马林固定石蜡包埋细胞块,包括 2 例伴无性细胞瘤的性腺母细胞瘤和 3 例转移性无性细胞瘤, 111 例涉及卵巢的非无籽肿瘤用 oct4 抗体染色。所有无性生殖细胞瘤和性腺母细胞瘤 OCT4 阳性,核染色强。每个病例中超过 90% 的无性细胞瘤细胞显示弥漫性强核染色。此外,3 例转移性无性生殖细胞瘤也显示出均匀的强核染色。所有非发育不良肿瘤 (成熟畸胎瘤,14; 卵黄囊瘤,4; 支持-Leydig 细胞瘤,15; 颗粒细胞瘤,22; 布伦纳瘤,3; 类癌瘤,4; 卵巢瘤,2; 纤维瘤,5; 卵泡膜瘤,1; 浆液性腺癌,5; 子宫内膜样腺癌,4;小细胞癌,6; 间质肉瘤,1; 恶性淋巴瘤,6; 转移性恶性黑素瘤,1; 转移性类癌,2; 转移性小细胞癌,1; 和转移性乳腺小叶癌,1) OCT4 阴性,除了一些卵巢透明细胞腺癌。14 个透明细胞腺癌中有 4 个显示 oct4 的局灶性阳性核免疫反应性。OCT4 是检测无性细胞瘤的敏感且相对特异的生物标志物。它也可能有助于性腺母细胞瘤的诊断,性腺母细胞瘤含有相似的细胞,可能与无性细胞瘤有关。OCT4 可能有助于检测卵巢外部位转移性无性细胞瘤的小病灶,也可能有助于区分无性细胞瘤与卵巢其他原发性和转移性肿瘤。

dysgerminoma

妇产 卵巢恶性生殖细胞肿瘤 疾病
概述  :  

无性细胞瘤(dysgerminoma)是一种由原始未定的生殖细胞异常增生形成的恶性肿瘤,无男性和女性化症状,故称为无性细胞瘤。无性细胞瘤为国外报道中最常见的卵巢恶性生殖细胞肿瘤,约占恶性生殖细胞肿瘤的50%。国内则为2、3位,占11%-20%。目前病因尚不明确,部分学者认为与生殖系统畸形有关,可伴有两性生殖系统畸形,临床上患者多以腹部症状就诊,多伴有血清LDH、碱性磷酸酶、血清甲胎蛋白或B-HCG升高。对放疗敏感。 特点 好发于青春期及生

dysgerminoma   /dis,dʒə:mi'nəumə/

释义    n. [肿瘤] 无性细胞瘤;未分化胚细胞瘤

例句    This is an ovarian dysgerminoma that has been sectioned into two halves.这是卵巢无性细胞瘤,已经被切成两半。

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