摘要

BACKGROUND:Hereditary angioedema (HAE) is a rare disorder caused by the deficiency of the C1-inhibitor gene (C1INH) . Patients experience recurrent bouts of edema, which can occur in almost any region of the body. As regards the treatment of the disease, danazol (an attenuated androgen) is used, among other agents, for long-term prophylaxis.
OBJECTIVE:The aim of this study was to investigate the possible adverse effects of danazol on serum lipid profile, as well as to ascertain whether danazol treatment is associated with an increased risk of atherosclerosis.
METHODS:Serum concentrations of total cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), triglycerides, apolipoprotein A-I, apolipoprotein B-100, and lipoprotein(a) were compared between danazol-treated patients with HAE and 2 control groups (ie, patients who did not receive long-term danazol prophylaxis and untreated healthy subjects).
RESULTS:Serum concentrations of HDL ( P = .0002 and P < .0001) and apolipoprotein A-I ( P = .0015 and P < .0001) were significantly lower, whereas LDL ( P = .0129 and P = .0127) and apolipoprotein B-100 ( P = .0456 and P = .0013) were higher in the danazol-treated patients compared with the 2 control groups, respectively. No significant difference was found in total cholesterol, triglyceride, or lipoprotein(a) levels. Patients who received danazol had an 11.6 (95% CI, 2.7-49.7) times higher risk for abnormally low HDL levels and a 4.4 (95% CI, 1.2-16.0) times lower risk for high LDL concentrations.
CONCLUSIONS:Our findings indicate that the long-term use of danazol is associated with an increased risk for early atherosclerosis in patients with HAE. Consequently, monitoring of HDL and LDL levels at regular intervals is recommended during follow-up.

译文

背景: 遗传性血管性水肿 (HAE) 是由 C1-inhibitor 基因 (C1INH) 缺失引起的一种罕见疾病。患者会经历反复发作的水肿,这种水肿几乎发生在身体的任何部位。关于这种疾病的治疗,除其他药物外,达那唑 (一种减弱的雄激素) 被用于长期预防。
目的: 本研究的目的是调查达那唑对血脂谱的可能不良影响,并确定达那唑治疗是否与动脉粥样硬化风险增加有关。
方法: 血清总胆固醇、高密度脂蛋白 (HDL) 、低密度脂蛋白 (LDL) 、甘油三酯、载脂蛋白 A-I 、载脂蛋白 B-100 和脂蛋白 (a) 的浓度比较了达那唑治疗的 HAE 患者和 2 个对照组 (即未接受长期达那唑预防的患者和未接受治疗的健康受试者)。
成果: 血清中 HDL 浓度 (P =。 0002 和 P <。 0001) 和载脂蛋白 A-I (P = 0。 0015 和 P <。 0001) 均显著降低,而 LDL (P = 0。 0129 和 P =。 0127) 和载脂蛋白 B-100 (P = 0。 0456 和 P =。 0013)分别与两个对照组相比,达那唑治疗的患者的发病率更高。总胆固醇、甘油三酯或脂蛋白 (a) 水平无显著差异。接受达那唑治疗的患者高密度脂蛋白水平异常低的风险为 11.6 (95% 置信区间,2.7-49.7) 和 4.4 (95% 置信区间,1.2-16.0) 降低高 LDL 浓度的风险。
结论: 我们的研究结果表明,长期使用达那唑与 HAE 患者早期动脉粥样硬化风险增加有关。因此,建议在随访期间定期监测高密度脂蛋白和低密度脂蛋白水平。

danazol

妇产 生殖内分泌疾病治疗 药物
概述  :  

达那唑(danzol)化学名为17-α孕甾-2,4-二烯-20-炔并[2,3-d]异恶唑-17β-醇,为弱雄激素,兼有蛋白同化作用及抗孕激素作用。临床用于治疗子宫内膜异位症、良性乳腺病 (如乳腺痛和纤维性乳腺炎)、男子乳房发育、功能性于宫出血及预防遗传性血管性水肿。也用于青春期、青春期早期的乳房肥大和各种血液疾病。   药理作用及代谢 达那唑是促性腺激素抑制药,可以抑制垂体-卵巢轴。通过抑制垂体促性腺激素分泌影响垂体-卵

danazol   ['dænəzɔ]

释    义    n. 达那唑;炔羟雄烯唑

例   句    The average time of menstruous restoration was earlier in mifepristone group than in that of danazol group. 

停药后米非司酮组月经平均恢复时间较达那唑组短。

请扫描右侧二维码,免费查看词汇专业知识背景