摘要

Inhibin is a heterodimeric TGFβ family ligand that is expressed in many cancers and is a selective biomarker for ovarian cancers; however, its tumor-specific functions remain unknown. Here, we demonstrate that the α subunit of inhibin (INHA), which is critical for the functionality of dimeric inhibin A/B, correlates with microvessel density in human ovarian tissues and is predictive of poor clinical outcomes in multiple cancers. We demonstrate that inhibin-regulated angiogenesis is necessary for metastasis. Although inhibin had no direct impact on tumor cell signaling, both tumor cell-derived and recombinant inhibin elicit a strong paracrine response from endothelial cells by triggering SMAD1/5 activation and angiogenesis in vitro and in vivo Inhibin-induced angiogenesis was abrogated via anti-inhibin α antibodies. The endothelial-specific TGFβ receptor complex comprising ALK1 and endoglin was a crucial mediator of inhibin signaling, offering a molecular mechanism for inhibin-mediated angiogenesis. These results are the first to define a role for inhibin in tumor metastasis and vascularization and offer an antibody-based approach for targeting inhibin therapeutically.Significance: Inhibin is a predictor of poor patient survival in multiple cancers and is a potential target for antiangiogenic therapies. Cancer Res; 78(11); 2978-89. ©2018 AACR.

译文

抑制素是一种异二聚体 tgf β 家族配体,在许多癌症中表达,是卵巢癌的选择性生物标志物; 然而,其肿瘤特异性功能仍未知。在此,我们证明了抑制素的 α 亚单位 (INHA),其对于二聚体抑制素 A/B 的功能是至关重要的, 与人类卵巢组织中的微血管密度相关,并可预测多种癌症的不良临床结果。我们证明抑制素调节的血管生成是转移所必需的。尽管抑制素对肿瘤细胞信号没有直接影响, 肿瘤细胞衍生的抑制素和重组的抑制素都可以通过激活 SMAD1/5 激活而引起内皮细胞强烈的旁分泌反应,体外和体内的血管生成抑制素诱导的血管生成通过抗抑制素 α 被清除。抗体。由 ALK1 和 endoglin 组成的内皮特异性 tgf β 受体复合物是抑制素信号的重要介质,为抑制素介导的血管生成提供了分子机制。这些结果首次定义了抑制素在肿瘤转移和血管化中的作用,并提供了一种基于抗体的治疗靶向抑制素的方法。意义: 抑制素是多种癌症患者生存不佳的预测因子,也是抗血管生成疗法的潜在靶点。癌症研究; 78 (11); 2978-89。©2018 AACR。

inhibin

妇产 性腺功能监测 临床研究术语
概述  :  

抑制素(inhibin,INH)属于转化生长因子β (TGF-β)多肽家族,是一种由女性卵巢颗粒细胞及男性睾丸支持细胞分泌的异二聚体蛋白质激素。它选择性抑制卵泡刺激素(FSH)的分泌,对性腺也有局部旁分泌作用。完整的抑制素分子是一个分子量约为32KD的分子,由两个不同的亚单位(a亚单位和b亚单位)经二硫键连接而成,即INH A(α-βA)和INH B(α-βB)。卵泡液和血清中也可以发现a亚单位。此外,游离的a亚单位与b亚单位没有生物活性。抑制素B主要作用是通过对F

inhibin  英 [ɪn'hɪbɪn]  美 [ɪn'hɪbɪn] 

释    义    n. 抑制素

例    句 

To investigate the expression of inhibin,epidermal growth factor receptor in human ovarian granulosa cell tumor and their clinical significance. 

研究抑制素、表皮生长因子受体在人卵巢颗粒细胞瘤中的表达及临床意义。

请扫描右侧二维码,免费查看词汇专业知识背景