摘要

MYC translocations are a defining feature of Burkitt lymphoma and a group of diffuse large B-cell lymphoma (DLBCL) with inferior outcome. However, the clinical relevance of MYC gene rearrangement and its relationship with MYC protein expression has not been well characterized in lymphomas. Tissue microarrays containing 1214 lymphomas were successfully evaluated by immunohistochemistry using anti-MYC clone Y69 and a dual-color break-apart fluorescence in situ hybridization probe to detect MYC gene rearrangements. Aggressive B-cell lymphomas including Burkitt lymphoma and DLBCL showed the highest level of MYC protein staining defined as staining in >50% of lymphoma cells. A significant proportion of plasmablastic, B-lymphoblastic and T-lymphoblastic, and extranodal NK/T-cell lymphomas also showed staining in >50% of cells, whereas only occasional plasma cell myeloma, mantle cell lymphoma, and classical Hodgkin lymphoma showed a high level of staining. Small B-cell lymphomas, when positive, showed MYC protein in <50% of cells. In aggressive B-cell lymphomas, MYC rearrangement and MYC immunohistochemistry showed a high concordance rate; however, some DLBCL and all T-cell and NK-cell lymphomas with MYC protein expression lacked MYC gene rearrangements. Our results provide a baseline for MYC protein expression in lymphomas and indicate that its expression is not specific to lymphoma subtypes, cell lineage, or expected clinical behavior and is highly variable. In addition, MYC protein expression is not necessarily correlated with MYC gene rearrangements and suggests the need for caution in the interpretation of MYC immunohistochemistry in the differential diagnosis of lymphomas. 

译文

MYC 易位是 Burkitt 淋巴瘤和一组预后较差的弥漫性大 b细胞淋巴瘤 (DLBCL) 的定义特征。然而,在淋巴瘤中,MYC 基因重排的临床相关性及其与 MYC 蛋白表达的关系尚未得到很好的描述。组织微阵列包含 1214 个淋巴瘤,通过免疫组织化学成功评估,使用抗-MYC 克隆 Y69 和双色分裂荧光原位杂交探针检测 MYC 基因重排。包括 Burkitt 淋巴瘤和 DLBCL 在内的侵袭性 b细胞淋巴瘤在> 50% 的淋巴瘤细胞中显示出最高水平的 MYC 蛋白染色,定义为染色。很大一部分浆母细胞、 B-淋巴母细胞和 T-淋巴母细胞以及结外 NK/T-细胞淋巴瘤也显示在> 50% 的细胞中染色,而只有偶尔的浆细胞多发性硬化, 套细胞淋巴瘤和经典型霍奇金淋巴瘤呈高水平染色。小 b细胞淋巴瘤,当呈阳性时,在 <50% 的细胞中显示出 MYC 蛋白。在侵袭性的 b细胞淋巴瘤中,MYC 重排和 MYC 免疫组织化学显示出很高的一致性率; 然而, 一些 DLBCL 的 T 细胞和 NK 细胞淋巴瘤 MYC 蛋白表达没有 MYC 基因重排。我们的结果为淋巴瘤中 MYC 蛋白表达提供了基线,并表明其表达对淋巴瘤亚型、细胞谱系或预期临床行为不具有特异性,并且具有高度可变性。此外,MYC 蛋白表达与 MYC 基因重排并不一定相关,这表明在淋巴瘤的鉴别诊断中,需要谨慎解释 MYC 免疫组织化学。

Myc gene

妇产 致癌基因检测 临床研究术语
概述  :  

Myc基因是较早发现的一组癌基因,属于编码核蛋白的癌基因,其编码一种与细胞周期调控有关的核内DNA结合蛋白。原癌基因Myc,是许多生长促进信号转录通路的交叉口,它是许多下游的配体-膜受体复合的一种立即早期反应基因。Myc的表达是高度调控的,其表达水平是通过涉及那些近端启动子区域中的多种转录调节模型机制控制。   在早期关于致癌反转录病毒导致肿瘤爆发的研究中发现了Myc通路,导致V形Myc基因引起髓细胞增生(白血病和肉瘤)。V形Myc基因从宿

Myc

释    义    n.原癌基因

例    句    That is because one of Dr Yamanaka's transcription factors, c-Myc, sometimes has theunfortunate side-effect of causing cancer.  Yamanaka博士发现的转录因子之一,c-Myc,有时会导致癌症的产生。

 

gene  英 [dʒiːn]   美 [dʒiːn] 

释    义    n. [遗] 基因,遗传因子  [复数 genes ]

例    句    We all know we are the product of our genes, what are all the steps from gene to us?  我们都知道基因决定了每个个体,但基因是如何使我们成为现在的我们的呢?

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