Expression of estrogen receptor alpha and beta mRNAs in prostate cancers treated with leuprorelin acetate.
醋酸亮丙瑞林治疗的前列腺癌中雌激素受体 α 和 β mrna 的表达。

摘要

OBJECTIVE:The discovery of a novel estrogen receptor (ER), ER-beta, has given rise to new possibilities regarding estrogen's roles in the prostate. Although ER-beta is reported to be expressed preferentially in the rat prostate, its expression in the human prostate and relationship to cancer development has not been investigated. Thus the purpose of the study was to examine mRNA levels of ER-alpha and ER-beta in benign prostatic hyperplasia and prostate carcinoma.
METHODS:Samples of 15 prostate cancers obtained at radical prostatectomy were examined. All the patients had been maintained on androgen withdrawal therapy for at least 3 months. ER-alpha and ER-beta mRNAs were measured with a competitive PCR technique.
RESULTS:Both ER-alpha and ER-beta mRNAs were detected in all of the prostate cancer tissues examined, as well as in PC3 and LNCap cells, although the levels varied among specimens. Interestingly, both types were significantly decreased in cases with lymph node metastasis. However, there was no correlation between ER mRNA levels and any other clinicopathological parameters.
CONCLUSIONS:(1) Both ER-alpha and ER-beta mRNAs are expressed in prostate cancer and (2) expression of ER mRNA may not be related to cancer progression but may be negatively correlated with metastasis.

译文

目的: 一种新的雌激素受体 (ER),ER-β 的发现,为雌激素在前列腺中的作用带来了新的可能性。尽管据报道 ER-β 在大鼠前列腺中优先表达,但其在人类前列腺中的表达及其与癌症发展的关系尚未被研究。因此,本研究的目的是检测良性前列腺增生和前列腺癌中 ER-α 和 ER-β 的 mRNA 水平。
方法: 对在前列腺癌根治术中获得的 15 例前列腺癌样本进行检查。所有患者均维持雄激素戒断治疗至少 3 个月。用竞争性 PCR 技术测量 ER-α 和 ER-β mrna。
结果: 在所有被检查的前列腺癌组织以及 PC3 和 LNCap 细胞中都检测到了 ER-α 和 ER-β mrna,尽管其水平在不同的样本中有所不同。有趣的是,在淋巴结转移的病例中,这两种类型都显著减少。然而,ER mRNA 水平与任何其他临床病理参数之间没有相关性。
结论 :( 1) ER-α 和 ER-β mrna 在前列腺癌中均有表达; (2) ER mRNA 的表达可能与癌症进展无关,但可能与转移呈负相关。

leuprorelin

妇产 妇科内分泌疾病治疗 药物
概述  :  

亮丙瑞林 (LE)是一种促性腺激素释放增效剂,可刺激垂体分泌促性腺激素,诱发生殖器官生成类固醇。长期使用会抑制促性腺激素及性腺甾体生成,1998年在法国批准上市,l992年获得我国进口药品许可证。目前主要应用于临床治疗子宫内膜异位症和子宫肌瘤等疾病。   适应证 子宫内膜异位症:对伴有月经过多、下腹痛、腰痛及贫血等的子宫肌瘤,可使肌瘤缩小和/或症状改善;对雌激素受体阳性的绝经前乳腺癌;前列腺癌;中枢性性早熟均有疗效。

leuprorelin   英 [l'ju:prəʊri:lɪn]   美 [l'juproʊrilɪn] 

释    义    [医] 亮丙瑞林

例    句   Conclusion: The molecular weight and first-order structure of leuprorelin acetate were confirmed.  结论:亮丙瑞林的分子量及一级结构与理论值相符。

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