微信扫码关注“小狗文献”

即刻体验更多权益

文献多,下载快,翻译准

首页 > 医学词汇大全 > cyproterone
cyproterone

妇产

关键词妇产 药物 激素调节

词汇介绍

拓展阅读

解析

cyproterone [saɪ'pratə,ron] 

释    义   n. 环丙孕酮

例    句   Objective To establish an accurate method for dissolution test of cyproterone acetate tablets.目的建立准确测定醋酸环丙孕酮片溶出度的方法。

概述

环丙孕酮(Cyproterone)是一种白色结晶性粉末状化学品,药物别名色谱龙,又称醋酸环丙孕酮,化学式为C24H29ClO4,几乎不溶于水,易溶于有机溶剂,避光。环丙孕酮为17-羟孕酮类衍生物,具有很强的抗雄激素作用,也有孕激素活性。能抑制垂体促性腺激素的分泌,使体内睾酮水平降低。 药理作用对于男性可抑制精子生成,减少精子数及其活动度,降低精液生化组成及精子穿透宫颈黏液的能力,但都是可逆的。其复方制剂-复方醋酸环丙孕酮片,其成分主要有炔雌醇,对于5α-还原酶活性具有抑制作用,对于

Genotoxic effects of 4-nonylphenol and Cyproterone Acetate on Rana catesbeiana (anura) tadpoles and juveniles复制标题

4-壬基酚和醋酸环丙孕酮对catesbeiana (anura) 蝌蚪和幼体的遗传毒性效应

发表时间:2019-08-01

影响因子:5.7

作者: L.S. Gregorio

期刊:Environ. Pollut

Cyproterone Acetate (CPA), present especially in drugs against prostate cancer and contraceptives, is also classified as an EDC due to the antiandrogenic, progestogen and antigonadotropic effects. Also, the available information concerning the CPA concentration in the aquatic environment is poor. Some predictive studies show a range of ng/L levels in France and in England and Whales, but the CPA was actually measured only in Malaysian rivers where the concentrations ranged from undetectable levels to 76 ng/L. Significant genotoxic effects were already observed on mammals exposed to different CPA concentrations, but studies on aquatic vertebrates, such as fish and amphibians, are still lacking. Thus, this study aims at evaluating whether different NP and CPA concentrations could induce nuclear abnormalities, such as micronucleus, buds and binucleated, anucleated and/or apoptotic cells, in the erythrocytes of Rana catesbeiana in different develop mental stages.

译文

醋酸环丙孕酮(CPA)由于具有抗雄激素、孕激素和抗性腺激素的作用,也被归类为EDC,尤其是在抗前列腺癌和避孕药物中。此外,关于CPA在水环境中的浓度的可用信息也很差。一些预测研究表明,在法国和英国和鲸鱼的Ng/L水平,但CPA实际上仅在马来西亚河流中测量,其中的浓度范围从不可检测水平到76 ng/L。在不同的CPA浓度的哺乳动物上已经观察到了显著的遗传毒性效应。但对鱼类、两栖类等水生脊椎动物的研究仍然缺乏。因此,本研究旨在探讨不同浓度的NP和CPA是否能诱发不同发育阶段蛙红细胞的微核、芽和双核、无核和/或凋亡细胞等核异常。