Genotoxic effects of 4-nonylphenol and Cyproterone Acetate on Rana catesbeiana (anura) tadpoles and juveniles复制标题

4-壬基酚和醋酸环丙孕酮对catesbeiana (anura) 蝌蚪和幼体的遗传毒性效应

Cyproterone Acetate (CPA), present especially in drugs against prostate cancer and contraceptives, is also classified as an EDC due to the antiandrogenic, progestogen and antigonadotropic effects. Also, the available information concerning the CPA concentration in the aquatic environment is poor. Some predictive studies show a range of ng/L levels in France and in England and Whales, but the CPA was actually measured only in Malaysian rivers where the concentrations ranged from undetectable levels to 76 ng/L. Significant genotoxic effects were already observed on mammals exposed to different CPA concentrations, but studies on aquatic vertebrates, such as fish and amphibians, are still lacking. Thus, this study aims at evaluating whether different NP and CPA concentrations could induce nuclear abnormalities, such as micronucleus, buds and binucleated, anucleated and/or apoptotic cells, in the erythrocytes of Rana catesbeiana in different develop mental stages.

译文