妇产
词汇介绍
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解析
cyproterone [saɪ'pratə,ron]
释 义 n. 环丙孕酮
例 句 Objective To establish an accurate method for dissolution test of cyproterone acetate tablets.目的建立准确测定醋酸环丙孕酮片溶出度的方法。
概述
4-壬基酚和醋酸环丙孕酮对catesbeiana (anura) 蝌蚪和幼体的遗传毒性效应
发表时间:2019-08-01
影响因子:5.7
作者: L.S. Gregorio
期刊:Environ. Pollut
Cyproterone Acetate (CPA), present especially in drugs against prostate cancer and contraceptives, is also classified as an EDC due to the antiandrogenic, progestogen and antigonadotropic effects. Also, the available information concerning the CPA concentration in the aquatic environment is poor. Some predictive studies show a range of ng/L levels in France and in England and Whales, but the CPA was actually measured only in Malaysian rivers where the concentrations ranged from undetectable levels to 76 ng/L. Significant genotoxic effects were already observed on mammals exposed to different CPA concentrations, but studies on aquatic vertebrates, such as fish and amphibians, are still lacking. Thus, this study aims at evaluating whether different NP and CPA concentrations could induce nuclear abnormalities, such as micronucleus, buds and binucleated, anucleated and/or apoptotic cells, in the erythrocytes of Rana catesbeiana in different develop mental stages.
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