Maximum androgen blockade using LHRH agonist buserelin in combination with short-term (two weeks) or long-term (continuous) cyproterone acetate is not superior to standard androgen deprivation in the treatment of advanced prostate cancer. Final analysis of EORTC GU Group Trial 30843. European Organization for Research and Treatment of Cancer (EROTC) Genito-Urinary Tract Cancer Cooperative Group.
使用 LHRH 激动剂 buserelin 联合短期 (两周) 或长期 (持续) 的最大雄激素阻断醋酸环丙孕酮在治疗晚期前列腺癌方面并不优于标准雄激素阻断。EORTC GU 集团试验 30843 的最终分析。欧洲癌症研究和治疗组织 (EROTC) 生殖-泌尿系统癌症合作小组。

摘要

This is the final analysis of EORTC GU Group Trial 30843 in which the treatment of advanced, metastatic prostate cancer with a combination of the LHRH agonist buserelin (nasal spray) and cyproterone acetate (Androcur), either continuously of only during the first 2 weeks, was compared with orchidectomy. There was no significant difference between the three arms as far as response rate, time to progression (subjective and objective) and duration of survival are concerned. Retrospective stratification according to the most important prognostic factors did not change the conclusions. Possible reasons for the difference with trial 30853, which used the same entry criteria but compared goserelin and flutamide with orchidectomy, are discussed. Reasons for using cyproterone acetate in combination treatment are the prevention of flare of the disease after LHRH agonists only and the prevention/reduction of toxicity in the form of hot flushes.

译文

这是 EORTC GU 小组试验 30843 的最终分析,其中使用 LHRH 激动剂 buserelin (鼻喷雾剂) 和醋酸环丙孕酮 (雄激素) 的组合治疗晚期转移性前列腺癌, 与兰花切除术相比,要么仅在头 2 周内连续进行。就反应率、进展时间 (主观和客观) 和生存时间而言,三组之间没有显著差异。根据最重要的预后因素进行回顾性分层没有改变结论。讨论了与试验 30853 不同的可能原因,该试验使用相同的进入标准,但将戈舍瑞林和氟他胺与兰花切除术进行了比较。在联合治疗中使用醋酸环丙孕酮的原因是仅在 LHRH 激动剂后预防疾病的爆发,以及以热潮红的形式预防/减少毒性。

cyproterone

妇产 激素调节 药物
概述  :  

环丙孕酮(Cyproterone)是一种白色结晶性粉末状化学品,药物别名色谱龙,又称醋酸环丙孕酮,化学式为C24H29ClO4,几乎不溶于水,易溶于有机溶剂,避光。环丙孕酮为17-羟孕酮类衍生物,具有很强的抗雄激素作用,也有孕激素活性。能抑制垂体促性腺激素的分泌,使体内睾酮水平降低。 药理作用对于男性可抑制精子生成,减少精子数及其活动度,降低精液生化组成及精子穿透宫颈黏液的能力,但都是可逆的。其复方制剂-复方醋酸环丙孕酮片,其成分主要有炔雌醇,对于5α-还原酶活性具有抑制作用,对于

cyproterone [saɪ'pratə,ron] 

释    义   n. 环丙孕酮

例    句   Objective To establish an accurate method for dissolution test of cyproterone acetate tablets.目的建立准确测定醋酸环丙孕酮片溶出度的方法。

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