摘要

Evidence suggests that a curvilinear relationship may exist between birth weight and later psychopathology. Increases in the prevalence of macrosomia and of two of its risk factors (maternal pre-pregnancy obesity and diabetes mellitus) and their amenability to intervention argue for a critical review of the association between macrosomia and mental illness. Of the nine studies in adults and six studies in youth that have examined associations between macrosomia and psychiatric disorders, seven have provided evidence suggestive of a link. Significant methodological variability and an inability to adjust for important confounders limit the findings of these studies. As a result, it remains unclear if individuals born macrosomic are at increased risk for psychopathology later in life. Future work should attempt to examine a broader range of psychiatric outcomes, use validated measures, include data on putative confounders and utilize genetically sensitive designs to assess associations between macrosomia, its precursors and later psychological and emotional functioning.

译文

证据表明,出生体重和后来的精神病理学之间可能存在曲线关系。巨大儿及其两个危险因素 (母亲孕前肥胖和糖尿病) 的患病率增加他们对干预的适应程度证明了对巨大儿和精神疾病之间联系的批判性审查。在九项针对成年人的研究和六项针对年轻人的研究中,有七项提供了暗示这种联系的证据。显著的方法学可变性和无法调整重要的混杂因素限制了这些研究的发现。因此,目前还不清楚出生巨大的个体在以后的生活中是否会增加患精神病理学的风险。未来的工作应该尝试检查更广泛的精神病学结果,使用有效的方法,包括假定的混杂因素数据,并利用基因敏感设计来评估巨大儿之间的联系, 它的前身和后来的心理和情感功能。

macrosomia

妇产 胎儿异常 疾病
概述  :  

巨大胎儿(macrosomia)指任何孕周胎儿体重超过4000g。还有一组以胎儿过度生长发育为特征的遗传综合征,称发育过度综合征。该类患儿出生后持续过度生长。近年来,因为人民生活条件的改善,营养过剩的孕妇有逐渐增多趋势,导致巨大胎儿的发生率增加较快,国内发生率约7%,国外发生率为15.1%,男胎多于女胎。有多种因素均可能造成巨大胎儿的出生,例如产妇肥胖、妊娠合并糖尿病、经产妇等,若未及时诊断干预,极易导致母婴健康受到威胁。所以了解巨大胎儿的相应因素,产前有效预测,选取适宜的分娩方式,降低并发

macrosomia  英 [mækrəʊ'səʊmɪə]  美 [mækroʊ'soʊmɪr]

释    义   n. 巨大发育;巨大症;巨大胎儿,巨体;巨型性,硕大态

例    句   The rate of Prgnancy - induced hypertension syndrome, polyhydramnios, dystocia , fetal death , stillbirth, fetal macrosomia increased owing GDM. 糖尿病对妊娠的影响可使妊高征、羊水过多、难产、死胎、死产、巨大儿等发生率增加。

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