摘要

BACKGROUND:Cigarette smoking is associated with earlier menopause, but the impact of being a former smoker and any dose-response relationships on the degree of smoking and age at menopause have been less clear. If the toxic impact of cigarette smoking on ovarian function is irreversible, we hypothesized that even former smokers might experience earlier menopause, and variations in intensity, duration, cumulative dose, and age at start/quit of smoking might have varying impacts on the risk of experiencing earlier menopause. METHODS AND FINDINGS:A total of 207,231 and 27,580 postmenopausal women were included in the cross-sectional and prospective analyses, respectively. They were from 17 studies in 7 countries (Australia, Denmark, France, Japan, Sweden, United Kingdom, United States) that contributed data to the International collaboration for a Life course Approach to reproductive health and Chronic disease Events (InterLACE). Information on smoking status, cigarettes smoked per day (intensity), smoking duration, pack-years (cumulative dose), age started, and years since quitting smoking was collected at baseline. We used multinomial logistic regression models to estimate multivariable relative risk ratios (RRRs) and 95% confidence intervals (CIs) for the associations between each smoking measure and categorised age at menopause (

译文

背景: 吸烟与更年期提前有关,但是以前吸烟和任何剂量反应关系对吸烟程度和更年期年龄的影响还不清楚。如果吸烟对卵巢功能的毒性影响是不可逆的,我们假设即使是以前的吸烟者也可能经历更年期更早,强度、持续时间、累积剂量、开始/戒烟的年龄可能对更年期提前的风险有不同的影响。方法和结果: 共有 207,231 和 27,580 名绝经后妇女分别被纳入横断面和前瞻性分析。他们来自 7 个国家 (澳大利亚、丹麦、法国、日本、瑞典、英国、美国) 的 17 项研究这为生殖健康和慢性病事件生命过程方法国际合作提供了数据 (交错)。在基线收集了吸烟状况、每天吸烟 (强度) 、吸烟持续时间、包装年 (累积剂量) 、开始年龄和戒烟后年数的信息。我们使用多项逻辑回归模型来估计多变量相对风险比 (RRRs) 和 95% 置信区间 (CIs),用于每个吸烟测量和更年期分类年龄之间的关联 (

menopause

妇产 妇女生命自然进程 临床研究术语
概述  :  

绝经(menopause)指妇女一生中的最后一次月经,只能回顾性地确定。绝经是妇女生命自然进程中的一个生理现象。绝经年龄受遗传、地理、营养、生活习惯、嗜烟酒与健康史等因素的影响。世界范围内自然绝经的年龄为45-55岁,平均为48-51岁。发达国家的绝经年龄中位数为50-52岁,发展中国家及亚非拉地区中位数为47岁左右。 分类及生理变化月经是每个正常女性都会有的一种情况,因为有了正常的月经出现,女性身体内部的激素才会正常,但是当女性们随着年龄的增长,月经的情况就可能会逐渐的发生改变,

menopause  英 [ˈmenəpɔːz]    美 [ˈmenəpɔːz]

释    义   n.绝经期;(妇女的)更年期          

同根词   menopausal   adj. 绝经期的,更年期的  

例    句   I'm going through menopause.  我大概到更年期了。

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