摘要

To clarify the role of biliary permeability in estrogen-induced intrahepatic cholestasis, long-term experiments were performed in rats using estradiol 17 beta-valerate. Bile flow, secretion of taurocholate, biliary clearance of [14C]sucrose and [14C]inulin, and phosphate concentration in bile were determined in hemoglobin-free perfused livers excised from male rats pretreated for different time periods. Basal and taurocholate-stimulated bile flow were already reduced during the first 7-10 days of treatment and remained at the lower level for more than 12 wk. In contrast, the concentration of taurocholate in bile was elevated at 7 and 10 days but was lower than in controls after 3 wk. An increase in [14C]sucrose clearance after 3 wk indicated a moderate increase in the permeability of a paracellular pathway. The concentration of phosphate in bile was also increased after 3 wk. Detailed analysis of biliary sucrose and inulin clearances revealed that the diffusion permeability coefficient (k = 0.14) did not increase during the first 10 days of treatment but did increase to greater than 0.4 after 3 wk of treating rats with estradiol 17 beta-valerate. From the temporal sequence of the cholestatic responses it is concluded that the altered permeability of the biliary tree is not the primary event but occurs subsequent to the cholestasis induced by estrogens.

译文

为了阐明胆汁通透性在雌激素诱导的肝内胆汁淤积中的作用,用 17 β-戊酸雌二醇对大鼠进行了长期实验。胆汁流动、牛磺胆酸盐的分泌、 [14C] 蔗糖和 [14C] 菊粉的胆汁清除、从经过不同时间预处理的雄性大鼠身上切下的无血红蛋白灌注肝脏,测定胆汁中的磷酸盐浓度。基础和牛磺胆酸刺激的胆汁流动在治疗的前 7-10 天已经减少,并在 12 周以上保持在较低水平。相反,胆汁中牛黄胆酸盐的浓度在 7 天和 10 天高,但在 3 周后低于对照组。3 周后 [14C] 蔗糖清除的增加表明细胞旁途径的渗透性适度增加。3 周后,胆汁中的磷酸盐浓度也增加了。对胆汁中蔗糖和菊粉清除率的详细分析表明,扩散渗透系数 (k = 0.14) 在治疗的头 10 天内没有增加,但在用 17 β-戊酸雌二醇治疗大鼠 3 周后,增加到大于 0.4。从胆汁淤积反应的时间序列可以得出结论,胆汁树的通透性改变不是主要事件,而是发生在雌激素诱导的胆汁淤积之后。

estradiol valerate

妇产 绝经后性激素治疗 药物
概述  :  

临床应用的雌激素包括天然萃取和人工合成,甾体类和非甾体类雌激素。非甾体类雌激素包括己烯雌酚和二酚己烷等现已停止应用。其中天然雌激素包括:妊马雌酮(又称倍美力,主要从孕马尿中萃取,含有100多种雌激素成分的激素)、戊酸雌二醇(商品名为补佳乐)、微粒化雌二醇。合成雌激素包括:雌激素酯类和17α乙炔基衍生物。炔雌醇(即乙炔雌二醇)为高效雌激素,由其联合组成的口服避孕药包括达英-35、妈富隆、优思明等);17-β-雌二醇:为高效雌激素,其复合制剂包括:芬吗通、安吉丽等均用于绝经后性激素治疗;苯甲酸雌

estradiol   [,estrə'daiəl]

释    义   n. 强力求偶素, [生化] 雌二醇

例    句   Serum testosterone and estradiol levels in 66 patients with acne and 20 normal persons were determined. 对66例痤疮患者和20例正常人的血清睾酮及雌二醇水平进行检测。

 

valerate   英 ['væləreit]  美 ['væləreit]

释    义   n. [有化] 戊酸盐;戊酸酯

例    句   Method: Treatment group and comparing group were treated with Guishen pill and estradiol valerate, progesterone respectively. 方法:治疗组与对照组分别口服中药归肾丸加味与戊酸雌二醇、黄体酮。

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