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estradiol valerate

妇产

关键词妇产 药物 绝经后性激素治疗

词汇介绍

拓展阅读

解析

estradiol   [,estrə'daiəl]

释    义   n. 强力求偶素, [生化] 雌二醇

例    句   Serum testosterone and estradiol levels in 66 patients with acne and 20 normal persons were determined. 对66例痤疮患者和20例正常人的血清睾酮及雌二醇水平进行检测。

 

valerate   英 ['væləreit]  美 ['væləreit]

释    义   n. [有化] 戊酸盐;戊酸酯

例    句   Method: Treatment group and comparing group were treated with Guishen pill and estradiol valerate, progesterone respectively. 方法:治疗组与对照组分别口服中药归肾丸加味与戊酸雌二醇、黄体酮。

概述

临床应用的雌激素包括天然萃取和人工合成,甾体类和非甾体类雌激素。非甾体类雌激素包括己烯雌酚和二酚己烷等现已停止应用。其中天然雌激素包括:妊马雌酮(又称倍美力,主要从孕马尿中萃取,含有100多种雌激素成分的激素)、戊酸雌二醇(商品名为补佳乐)、微粒化雌二醇。合成雌激素包括:雌激素酯类和17α乙炔基衍生物。炔雌醇(即乙炔雌二醇)为高效雌激素,由其联合组成的口服避孕药包括达英-35、妈富隆、优思明等);17-β-雌二醇:为高效雌激素,其复合制剂包括:芬吗通、安吉丽等均用于绝经后性激素治疗;苯甲酸雌

Difffferential expression of μ-opioid receptors in the nucleus accumbens, Difffferential expression of μ-opioid receptors in the nucleus accumbens复制标题

伏核 μ-阿片受体的差异表达,伏核 μ-阿片受体的差异表达

发表时间:2019-09-21

影响因子:2.8

作者: L.M. Molina-Martínez

期刊:Behav. Brain Res

Research has also described that β-end plasma levels are lower in chronic alcoholics than non-alcoholics. Likewise, reports have shown that β-end levels in the cerebrospinal fluid of alcoholics may be 3 times lower than in non-alcoholics. This has led to the proposal that a central β-end deficiency generates exacerbated alcohol consumption, apparently in an attempt to compensate for this shortage, while simultaneously increasing the gratifying effffect of alcohol. In this regard, substantial evidence indicates that prolonged exposure to supra-physiological levels of estrogen in female rats induced by a single dose of estradiol valerate (EV; 2 mg/rat) promotes chronic anovulation and the formation of polycystic ovaries, followed by a neurotoxic effect on ArN β-end neurons.

译文

研究还表明,慢性酗酒者的β-端血浆水平低于非酗酒者。同样,有报道显示,酗酒者脑脊液中的β-末端水平可能比非酗酒者低3倍这导致了一种观点,即中心β-末端缺陷会导致酒精消耗加剧,显然是为了弥补这一不足,同时增加酒精的令人满意的效果。在这方面,大量证据表明,长期暴露于雌性大鼠雌激素水平的超生理水平由单一剂量的戊酸雌二醇(EV;2毫克/大鼠)促进慢性排卵和多囊卵巢的形成,继而对ARNβ端神经元产生神经毒性作用。