spironolactone 英 [,spaɪrənə(ʊ)'læktəʊn] 美 [spaɪ'rɒnə'lækton]
释 义 n. 安体舒通，螺内酯，螺旋内酯甾酮（一种利尿药）
例 句 The mechanism of the effects of spironolactone on the endocrine system is unclear. 螺内酯对内分泌系统的影响机制尚不清楚。
作者： Macarena Alpañés
期刊：Eur. J. Endocrinol
COC remain the mainstay of the pharmacological therapy of PCOS. Although the practice of adding an antiandrogen to COC may be controversial antiandrogens such as spironolactone are clinically effective for treating hirsutism and may be beneficial for the dermatologic manifestations of PCOS in some cases. However, concerns about the metabolic and cardiovascular safety of COC explain the ongoing debate about the drug of choice for the long-term management of these women.The increase in blood pressure during treatment with COC might be prevented, at least in theory, by the addition of spironolactone. This steroidal antiandrogen and antihypertensive drug is usually administered to hyperandrogenic women with PCOS in combination with a COC with the aim of preventing the frequent development of menstrual disturbances or even amenorrhea, and also to avoid feminization of a male fetus if unnoticed pregnancy occurs.