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Biomarker-based phenotyping of myocardial fibrosis identifies patients with heart failure with preserved ejection fraction resistant to the beneficial effects of spironolactone: results from the Aldo-DHF trial.
基于生物标志物的心肌纤维化表型鉴定具有抗螺内酯有益作用的射血分数保留的心力衰竭患者: 来自 Aldo-DHF 试验的结果。
Biomarkers of myocardial fibrosis Carboxy-terminal propeptide of procollagen type I Carboxy-terminal telopeptide of collagen type I Heart failure with preserved ejection fraction Left ventricular diastolic function Matrix metalloproteinase-1 Spironolactone
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摘要

BACKGROUND:Myocardial fibrosis is characterized by excessive cross-linking and deposition of collagen type I and is involved in left ventricular stiffening and left ventricular diastolic dysfunction (LVDD). We investigated whether the effect of spironolactone on LVDD in patients with heart failure with preserved ejection fraction (HFpEF) depends on its effects on collagen cross-linking and/or deposition.
METHODS AND RESULTS:We investigated 381 HFpEF patients from the multicentre, randomized, placebo-controlled Aldo-DHF trial with measures of the E:e' ratio. The ratio of serum carboxy-terminal telopeptide of collagen type I to serum matrix metalloproteinase-1 (CITP:MMP-1, an inverse index of myocardial collagen cross-linking) and serum carboxy-terminal propeptide of procollagen type I (PICP, a direct index of myocardial collagen deposition) were determined at baseline and after 1-year treatment with spironolactone 25 mg once daily or placebo. Patients were classified by CITP:MMP-1 and PICP tertiles at baseline. While CITP:MMP-1 tertiles at baseline interacted (P 

译文

背景: 心肌纤维化以 I 型胶原的过度交联和沉积为特征,并参与左心室硬化和左心室舒张功能障碍 (LVDD)。我们研究了螺内酯对射血分数保留的心力衰竭 (HFpEF) 患者 LVDD 的影响是否取决于其对胶原交联和/或沉积的影响。
方法和结果: 我们调查了 381 名来自多中心、随机、安慰剂对照的 Aldo-DHF 试验的 HFpEF 患者,并测量了 E: E '比值。I 型胶原的血清羧基末端肽与血清基质 metalloproteinase-1 的比值 (CITP: MMP-1,心肌胶原交联的反比指数) 在基线和每天一次用螺内酯 25 毫克或安慰剂治疗 1 年后,测定血清 ⅰ 型前胶原羧基末端肽 (PICP,心肌胶原沉积的直接指标)。患者按 CITP 分类: 基线时 MMP-1 和 PICP tertiles。而 CITP: MMP-1 在基线时相互作用 (p  

spironolactone

妇产 生殖内分泌疾病药物 药物
概述  :  

螺内酯是人工合成的甾体化合物,是一种低效利尿剂,可治疗水肿性疾病,也具有治疗原发性醛固酮增多症。对于女性来说,这个药物一方面可以治疗原发性醛固酮增高症,另一方面也可以治疗低钾血症,高血压疾病。 药理毒理本药结构与醛固酮相似,为醛固酮的竞争性抑制剂。由于本药仅作用于远曲小管和集合管,对肾小管其他各段无作用,故利尿作用较弱。另外,螺内酯对肾小管以外的醛固酮靶器官也有作用。本药口服吸收较好,生物利用度大于90%,血浆蛋白结合率在90%以上,进入体内后80%由肝脏迅速代谢为有活性的坎利酮(

spironolactone  英 [,spaɪrənə(ʊ)'læktəʊn] 美 [spaɪ'rɒnə'lækton]

释    义   n. 安体舒通,螺内酯,螺旋内酯甾酮(一种利尿药)

例    句   The mechanism of the effects of spironolactone on the endocrine system is unclear. 螺内酯对内分泌系统的影响机制尚不清楚。

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