Tropism of the in situ growth from biopsies of childhood neuroectodermal tumors following transplantation into experimental teratoma.
儿童神经外胚层肿瘤移植到实验性畸胎瘤后活检原位生长的趋向性。
biopsy childhood human in vivo model neuroectodermal tumor stem cells
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摘要

Experimental teratoma induced from human pluripotent stem cells with normal karyotype can be described as a failed embryonic process and includes besides advanced organoid development also large elements of tissue with a prolonged occurrence of immature neural components. Such immature components, although benign, exhibit strong morphological resemblance with tumors of embryonic neuroectodermal origin. Here, we demonstrate that biopsy material from childhood tumors of neural embryonic origin transplanted to mature experimental teratoma can show an exclusive preference for matching tissue. Tumor specimens from five children with; Supratentorial primitive neuroectodermal tumor (sPNET); Pilocytic astrocytoma of the brainstem; Classic medulloblastoma; peripheral primitive neuroectodermal tumor (pPNET) or neuroblastoma (NB), respectively, were transplanted. Analysis of up to 120 sections of each tumor revealed an engraftment for three of the transplanted tumors: pPNET, sPNET, and NB, with a protruding growth from the latter two that were selected for detailed examination. The histology revealed a strict tropism with a non-random integration into what morphologically appeared as matched embryonic microenvironment recuperating the patient tumor histology. The findings suggest specific advantages over xenotransplantation and lead us to propose that transplantation to the human embryonic microenvironment in experimental teratoma can be a well-needed complement for preclinical in vivo studies of childhood neuroectodermal tumors. 

译文

由染色体组型正常的人多能干细胞诱导的实验性畸胎瘤可以被描述为一个失败的胚胎过程,除了高级器官样发育外,还包括组织的大元素和不成熟神经成分的长期出现。这种不成熟的成分,虽然是良性的,但与胚胎神经外胚层起源的肿瘤表现出很强的形态相似性。在这里,我们证明了从神经胚胎起源的儿童肿瘤移植到成熟的实验性畸胎瘤的活检材料可以显示出对匹配组织的独家偏好。5 例儿童肿瘤标本; 幕上原始神经外胚层肿瘤 (sPNET); 脑干毛细胞型星形细胞瘤; 经典髓母细胞瘤; 外周原始神经外胚层肿瘤 (pPNET) 或神经母细胞瘤 (NB), 被移植了。对每个肿瘤多达 120 个部分的分析揭示了三种移植肿瘤的植入: pPNET 、 sPNET 和 NB, 从后两者中突出生长,被选择进行详细检查。组织学揭示了一种严格的趋向性,即非随机整合到形态学上看起来匹配的胚胎微环境中,以恢复患者的肿瘤组织学。这些发现表明了与异种移植相比的特殊优势,并使我们提出在实验性畸胎瘤中移植到人类胚胎微环境可以成为儿童神经外胚层肿瘤临床前体内研究的必要补充。

teratoma

妇产 卵巢癌 疾病
概述  :  

畸胎瘤是卵巢肿瘤中常见的一种,来源于生殖细胞,分为成熟畸胎瘤(即良性畸胎瘤)和未成熟性畸胎瘤(恶性畸胎瘤)。良性畸胎瘤里含有很多种成分,包括皮肤、毛发、牙齿、骨骼、油脂、神经组织等;恶性畸胎瘤分化欠佳,没有或少有成形的组织,结构不清。早期畸胎瘤多无明显临床症状,大多是体检时偶然发现。卵巢成熟性畸胎瘤(MCTO),亦称皮样囊肿,是育龄期女性最常见的生殖细胞肿瘤 ,约占卵巢肿瘤10%~20%。MCTO可由一个或多个胚层的成熟组织组成,为卵巢良性肿瘤, 罕有恶性变,文献报道恶变率为1%~2%。&n

teratoma  英 [,terə'təʊmə]   美 [,terə'təumə]

释    义   畸胎瘤;卵巢畸胎瘤;囊性畸胎瘤

例    句   Their tumor pathologies included benign or malignant thymoma and teratoma.  他们的肿瘤病理包括良性或恶性胸腺瘤和畸胎瘤。

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