A review of a series of 70 Krukenberg tumors seen in consultation disclosed 13 cases with a predominant tubular pattern. Eleven of them had been diagnosed by the referring pathologist as a tumor in the sex cord-stromal category, usually a Sertoli-Leydig cell tumor; no diagnosis was preferred in the other two cases. Three factors contributed to the erroneous diagnoses: a prominent tubular pattern, luteinization of the stroma of the tumor in five cases, and associated virilization in two cases. Each tumor, however, contained typical signet-ring cells that were readily demonstrable with mucicarmine stains. In six cases the tumors were unilateral and in seven, bilateral. Ten patients died of their cancer from 2 to 21 months after the diagnosis had been made. In one case the ovarian tumors were not discovered until autopsy. Two patients are alive 7 and 9 months postoperatively. A primary tumor was found in the stomach in four cases and in the sigmoid colon and appendix in one each. No primary tumor was found in seven cases but an autopsy had been performed in only one of these. The diagnosis of Krukenberg tumor must always be considered in the differential diagnosis of an ovarian tumor with a tubular pattern even though endocrine manifestations are present.
对咨询中看到的一系列 70 例 Krukenberg 肿瘤的回顾揭示了 13 例以管状模式为主的病例。其中 11 人已被转诊病理学家诊断为性索间质肿瘤，通常为支持-睾丸间质细胞肿瘤; 在另外两个病例中没有首选诊断。三个因素导致了错误的诊断: 一个突出的管状模式，五例肿瘤基质的黄体化，两例相关的男性化。然而，每个肿瘤都含有典型的印戒细胞，这些细胞很容易被粘液染色证明。在六个病例中，肿瘤是单侧的，在七个病例中，肿瘤是双侧的。在诊断出来后的 2 到 21 个月内，有 10 名患者死于癌症。在一个病例中，卵巢肿瘤直到尸检才被发现。两名患者术后 7 个月和 9 个月存活。在胃中发现了一个原发性肿瘤，有四个病例，乙状结肠和阑尾各有一个。七个病例中没有发现原发性肿瘤，但其中只有一个病例进行了尸检。尽管存在内分泌表现，但在对管状卵巢肿瘤进行鉴别诊断时，必须始终考虑 Krukenberg 肿瘤的诊断。
Tubular Krukenberg tumor. A problem in histopathologic diagnosis.
库肯勃氏瘤（krukenberg tumor)是实性，肾形，双侧性的转移性卵巢癌，一般保存卵巢的外形，与其他器官多无粘连，直经平均10-15厘米，多伴有腹水。切面呈胶质样，可有出血及坏死，并可发生自发性破裂及腹腔出血，镜下有结缔组织增生及分泌粘液的印戒样细胞。肿瘤多来自胃，也可来自胆囊，乳腺及结肠，偶然可未见原发病灶。一般认为转移途径系经腹主动脉淋巴倒流。 库肯勃瘤是卵巢转移瘤的一种，指肿瘤生长在卵巢内库肯勃瘤是指卵巢发生印戒细胞伴间质假肉瘤样增生的转移瘤。病理学上印戒细胞的定义是
释 义 n. 库肯勃；克鲁肯伯格；克鲁肯贝格
例 句 Primary Ovarian Tumors and Krukenberg Tumors: Confusing Areas of Diagnosis. 易与库肯勃瘤混淆的几类卵巢原发性肿瘤。
tumor 英 ['tjuːmə(r)] 美 ['tjʊmɚ]
释 义 n. 肿瘤；肿块；赘生物
例 句 Just a few tumor cells in blood are enough to spread cancer to other parts of the body. 在血液中，仅少数肿瘤细胞就可以将癌症转移到身体的其他部分。