内分泌
词汇介绍
拓展阅读
解析
dexamethasone 英/,deksə'meθəsəʊn; -zəʊn/ 美 /,dɛksə'mɛθə,son; ,dɛksə'mɛθə,zon/
释 义 n. [药] 地塞米松;氟美松(抗炎药)
例 句 Purpose To study the permeability of dexamethasone through cryopreserved amniotic membrane. 目的研究冷冻保存羊膜对地塞米松的通透性。
suppression 英 /səˈpreʃn/ 美 /səˈpreʃn/
释 义 n. 抑制;镇压;[植] 压抑
同根词 suppressed adj. 抑制的,发育不全的
suppressant n. 抑制药
suppressed v. 镇压,禁止
suppress vt. 抑制;镇压;废止
例 句 Because of the great cause of this suppression of the weak sentiments .因为伟大的事业抑制了这种软弱的感情。
test 英 /test/
释 义 n. 测验,考查;测试;检验;化验
v. 测验;化验,检查;试验,测试;考验
例 句 Please don't, if you are up here, become complacent because a month from now we will have another test.如果你考得不错的话,请不要自满,因为在一个月后我们将还有一次测试。
概述
The Very Low-Dose Dexamethasone Suppression Test in the General Population: A Cross-Sectional Study复制标题
普通人群的极低剂量地塞米松抑制试验: 一项横断面研究
发表时间:2016-11-01
影响因子:2.8
作者: Nese Direk
期刊:PLoS One
The hypothalamic-pituitary-adrenal (HPA) axis controls the stress response in the body. To explain the relation between diurnal HPA axis functioning and metabolic or stress-related disorders in large cohorts of healthy persons, researchers relied on single morning blood measures or used repeated saliva sampling. Different measures of the HPA axis such as cortisol awakening response, diurnal decline and total cortisol exposure over the day have been assessed using mostly saliva. More recently, cortisol assessment in hair became possible. In contrast, negative feedback of the HPA axis is rarely tested in non-clinical studies. In clinical populations, the negative feedback of the HPA axis is assessed by a dexamethasone suppression test (DST) requiring oral administration of a dose of dexamethasone. Cortisol secretion after dexamethasone intake is typically suppressed. A non-suppression indicates hypercortisolemia but DST proved very difficult to implement in population-based studies. The DST was originally designed to diagnose patients with Cushing’s Syndrome using 1 mg or higher doses of dexamethasone with a cut-off value for the plasma cortisol to distinguish between non-suppressors and suppressors. A dose of 1 mg in the conventional DST fully suppresses the HPA axis in most persons from a non-clinical population. Furthermore, the traditional “black and white” outcome definition of the negative feedback of the HPA axis masks any variation across the continuum of HPA axis reactivity. To this aim, cut-points were defined for the conventional DST, which relies on plasma cortisol to define suppression. In this population-based study, we tested the determinants of the negative feedback of the HPA axis with a very low-dose DST (0.25 mg) and assessed the outcome (suppression) continuously. Different determinants of the suppression or non-suppression after DST have been explored in the last decades. Over the years, the DST became perhaps the most common function test in clinically depressed persons. However, like in other psychiatric disorders including post-traumatic stress disorders, anxiety disorders, eating disorders, psychosis, personality traits, results of this test are inconsistent.
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