摘要

PurposeAdults with Turner syndrome (TS) have an increased predisposition to ischemic heart disease. The quantitative relationship between coronary atherosclerosis and TS has yet to be established.MethodsA total of 128 females (62 with TS) participated in this prospective study. Coronary computed tomography angiography was performed to measure coronary calcified plaque burden, and prevalent noncalcified plaque burden. Regression analysis was used to study the effects of TS and traditional cardiovascular disease risk factors on coronary plaque burden.ResultsAdults with TS were 63% more likely to have coronary calcifications than controls (odds ratio 1.63, 95% confidence interval: 1.02, 2.61, P = 0.04), with an age cutoff of 51.7 years for a probability of >50% for the presence of coronary calcifications, when compared to 55.7 years in female controls. The average age of TS patients with calcified plaques was significantly lower than that of controls with calcified plaques (51.5 ± 8.9 years vs. 60.5 ± 7.0 years, P 

译文

目的患有特纳综合征 (TS) 的成年人对缺血性心脏病的倾向增加。冠状动脉粥样硬化与 TS 之间的定量关系尚未建立。方法共有 128 名女性 (62 名 TS 患者) 参与了这项前瞻性研究。进行冠状动脉计算机断层扫描血管造影术来测量冠状动脉钙化斑块负荷和普遍的非钙化斑块负荷。采用回归分析研究 TS 和传统心血管疾病危险因素对冠状动脉斑块负荷的影响。结果与对照组相比,TS 患者发生冠状动脉钙化的可能性高 63% (比值比 1.63,95% 置信区间: 1.02,2.61,p =-0。 04),与女性对照组的 51.7 年相比,年龄截止为 50% 年,存在冠状动脉钙化的概率> 55.7。有钙化斑块的 TS 患者的平均年龄明显低于有钙化斑块的对照组 (51.5 ± 8.9 岁 vs.60.5 ± 7.0 岁,p  

Turner syndrome

内分泌 染色体异常 疾病
概述  :  

当X染色体(性染色体)之一缺失或部分缺失时,会导致特纳综合症(仅影响女性)。特纳综合征(TS)可引起多种医学和发育问题,包括身高矮,卵巢发育异常和心脏缺陷。特纳综合征可以在出生前(产前),婴儿期或儿童早期诊断出来。有时,具有特纳综合征症状和体征的女性中,可能推迟到成年或成年后才诊断出来。患有特纳氏综合症的女孩和妇女需要进行定期检查和适当照顾,这些可以帮助大多数女孩和妇女过上健康、独立的生活。病理机制大多数人天生就有两个性染色体。男孩从母亲那里继承X染色体,从父亲那里继承Y染色体。女孩从父母那

Turner   英 /'tɜːnə/   美 /'tɝnɚ/

释    义   n. 特纳(姓氏)

例    句   Turner inherited the right to fish at this spot from his father. 特纳从父亲那里继承了在这个地点捕鱼的权利。

 

Syndrome   英 /ˈsɪndrəʊm/   美 /ˈsɪndroʊm/

释    义   n. [临床] 综合症状;并发症状;校验子;并发位

例    句   Women complain about premenstrual syndrome, but I think of it as the only time of the month that I can be myself. 女人会抱怨经前期综合症,但是我认为这是一个月中我唯一可以做回我自己的日子。

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