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首页 > 医学词汇大全 > Thyroid Cancer
Thyroid Cancer

内分泌

关键词内分泌 疾病 甲状腺

词汇介绍

拓展阅读

解析

thyroid   英 /'θaɪrɒɪd/   美 /'θaɪrɔɪd/

       n. 甲状腺;甲状软骨;甲状腺剂;adj. 甲状腺的;盾状的

同根词   thyroidectomy n. [外科] 甲状腺切除术

       I believe that thyroid hormone treatment should not be given to all overweight subjects. 我相信甲状腺激素治疗并不适用于所有的肥胖病人。

 

cancer   英 /'kænsə/  美 /kænsə/

       n. 癌症;恶性肿瘤

同根词   cancerous adj. 癌的;生癌的;像癌的

       However, they appear to be at lower risk of death from cancer. 然而,面对癌症死亡,他们似乎有一个较低的风险。

概述

与其他癌症相比,甲状腺癌相对罕见。甲状腺癌通常是可治疗的,并且通常通过手术治愈,如果有必要,可选择放射性碘治疗。即使癌症的诊断是可怕的,但大多数乳头状和滤泡性甲状腺癌患者的预后通常也很好。诊断方法甲状腺结节的细针穿刺活检的结果可以提示甲状腺癌的诊断,并且可以通过手术切除结节后确定。虽然甲状腺结节很常见,但不到十分之一的甲状腺结节是甲状腺癌。治疗方法手术:分化型甲状腺癌的手术范围将取决于肿瘤的大小以及肿瘤是否局限于甲状腺。手术后,大多数患者需要在其余生中服用甲状腺激素。通常,甲状腺癌仅通过手术

Thyroglobulin washout from cervical lymph node fine needle aspiration biopsies in patients with differentiated thyroid cancer: an analysis of different expressions to use in post-total thyroidectomy follow-up复制标题

分化型甲状腺癌患者颈淋巴结细针穿刺活检中甲状腺球蛋白的清除: 甲状腺全切除术后随访中不同表达的分析

发表时间:2019-09-05

影响因子:3.5

作者: Bora Kahramangil

期刊:Surgery

This study presents an objective comparison of different methods that may be used to interpret TGW levels from suspicious cervical LNs in the follow-up of DTC. Despite TGW having a high accuracy to detect metastasis, different types of calculations have certain limitations in various clinical scenarios. The use of TGW to detect thyroid cancer metastasis was first described by Pacini et al in 1992.9 Since then, other studies have also reported its usefulness in this regard. Despite an increasing number of studies in this field, TGW literature suffers from a lack of standardization of patient selection, biopsy technique, and analytical methods. Different cutoffs to diagnose nodal metastasis in various clinical scenarios have been proposed over the years. In the leading studies, proposed cutoffs include 1 ng/ml in athyrotic patients, 1 ng/ml in all patients regardless of presence or absence of the thyroid, and 32 ng/ml in patients with intact thyroids. Another suggested strategy to maximize the usefulness of TGW was to interpret the washout Tg concentrations in the context of serum Tg. Nevertheless, TGW remains difficult to interpret in clinical practice. The use of Tg concentration in the washout is easy without a need for additional calculations. However, it does not take into account the contamination from serum. This may become a problem in patients with high serum Tg titers, causing false positives. Although TGW/serum Tg concentration ratio eliminates this bias, the ratio cannot be calculated when serum Tg is undetectable. ATC, on the other hand, provides a single metric, which can be used in all patients and corrects for technical variations and serum contamination. In the literature, there is a lack of standardization of TGW techniques. In our clinical practice, we rinse the aspirate in 5 ml of normal saline. Balok et al have described a technique using 1 ml of normal saline for rinsing. Snozek et al, on the other hand, sampled each LN with a separate needle for 3 to 6 times, rinsed each needle with 0.1 to 0.5 ml of normal saline, and pooled all the washes in a single specimen.12 These variations in the performance of TGW can lead to different degrees of dilution and would limit the applicability of a cutoff obtained from one center’s series to other centers using a different technique.

译文

本研究提出了不同方法的客观比较,可用于解释DTC随访中可疑宫颈LN的TGW水平。尽管TGW具有检测转移的高准确度,但是不同类型的计算在各种临床情况下具有某些限制。 Pacini等人在1992年首次描述了使用TGW检测甲状腺癌转移.9从那时起,其他研究也报道了其在这方面的用途。尽管该领域的研究越来越多,但TGW文献仍然缺乏患者选择,活检技术和分析方法的标准化。多年来已经提出了在各种临床情况下诊断淋巴结转移的不同截止值。在领先的研究中,提出的临界值包括1 ng / ml的患者,所有患者均为1 ng / ml,无论甲状腺是否存在,患有完整甲状腺的患者为32 ng / ml。另一种使TGW有用性最大化的策略是在血清Tg的背景下解释冲洗Tg浓度。然而,TGW在临床实践中仍难以解释。在冲洗中使用Tg浓度是容易的,无需额外的计算。但是,它没有考虑到血清污染。这可能成为具有高血清Tg滴度的患者的问题,导致假阳性。尽管TGW /血清Tg浓度比消除了这种偏差,但是当血清Tg不可检测时,不能计算该比率。另一方面,ATC提供单一指标,可用于所有患者并纠正技术变化和血清污染。在文献中,缺乏TGW技术的标准化。在我们的临床实践中,我们用5毫升生理盐水冲洗吸出物。 Balok等人描述了使用1ml生理盐水冲洗的技术。另一方面,Snozek等人用单独的针对每个LN进行3至6次取样,用0.1至0.5ml生理盐水冲洗每根针,并将所有洗涤液汇集在一个样品中.12这些性能变化TGW会导致不同程度的稀释,并且会限制使用不同技术从一个中心系列获得的截止值对其他中心的适用性。