Drug nanoparticles Fenofibrate Stirred media milling Ultrasonication
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摘要

The production of fenofibrate nanoparticles combining stirred media milling and ultrasonication method was investigated in the current work. The fenofibrate drug sample was first wet milled in stirred media mill for different times and subsequently processed by ultrasonication. The effects of ultrasonication time, power on final product particle sizes were studied. The pre milling by stirred media milling was resulted into reduction of comminution resistance of material. Subsequent treatment by ultrasonication produced smaller particles than obtained by stirred media milling alone. The resulting nanoparticles were found to exhibit excellent stability as investigated by particle size, zeta potential, and multiple light scattering measurement techniques. Further, qualities of nanoparticles obtained by combined approach were characterized by TEM and XRD analysis. 

译文

本工作研究了搅拌介质研磨和超声波相结合的非诺贝特纳米颗粒的生产。非诺贝特药物样品首先在搅拌介质研磨机中湿磨不同时间,然后用超声波处理。研究了超声时间、功率对最终产品粒度的影响。通过搅拌介质铣削预磨可降低材料的粉碎阻力。随后超声波处理产生的颗粒比单独搅拌介质研磨获得的颗粒更小。通过粒径、 zeta 电位和多重光散射测量技术的研究,发现所得纳米粒子表现出优异的稳定性。此外,通过 TEM 和 XRD 分析,用组合方法获得的纳米粒子的质量进行了表征。

Fenofibrate

内分泌 降血脂类药物 治疗药物
概述  :  

非诺贝特与低脂饮食,运动,有时与其他药物一起使用,以减少血液中胆固醇和甘油三酯等脂肪物质的含量,并增加HDL的含量,降低心脏病的风险。尽管非诺贝特降低了血液中脂肪物质的含量,但尚未证实可降低心脏病发作或中风的风险。非诺贝特属于一类叫做抗血脂药的药物。适应症非诺贝特与适当的饮食一起使用,以帮助降低“坏”胆固醇和脂肪(如低密度脂蛋白,甘油三酯),并提高血液中的“好”胆固醇(HDL)。它的作用是增加分解血液中脂肪的天然物质(酶)。非诺贝特属于一组被称为“贝特类”的药物,降低甘油三酯水平高的人群中的

Fenofibrate

       n. 非诺贝特

       Objective To discuss the value of simvastatin plus fenofibrate for the treatment of mixed hyperlipemia. 目的探讨辛伐他汀联合非诺贝特治疗混合性高脂血症的价值。

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