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首页 > 医学词汇大全 > Triiodothyronine
Triiodothyronine

内分泌

关键词内分泌 诊断指标 甲状腺激素

词汇介绍

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解析

triiodothyronine   英 /traɪ,aɪədə(ʊ)'θaɪrəniːn/   美 /aɪədo'θaɪrənin/

释    义   n. 三碘甲状腺氨酸

例    句   Triiodothyronine (T3) and insulin can promote the cell's metabolism of sugar, fat and protein, and accelerate the cell's growth. 三碘甲状腺原氨酸(T3)和胰岛素能促进糖、脂肪和蛋白质三大物质的代谢,加速细胞的氧化过程。

概述

三碘甲腺原氨酸,也称为T3,是一种甲状腺激素。它几乎影响身体的每一个生理过程,包括生长发育,新陈代谢,体温和心率。机制T3和T4与核受体(甲状腺激素受体)结合。T3和T4虽然是亲脂性的,但不能被动地扩散通过靶细胞的磷脂双层,而是依赖于跨膜碘甲状腺原氨酸转运蛋白。T3和T4的亲脂性需要它们与蛋白质载体甲状腺结合蛋白(TBG)结合(甲状腺素结合球蛋白,甲状腺素结合前白蛋白和白蛋白)用于血液中的运输。甲状腺受体与基因启动子中的反应元件结合,从而使它们能够激活或抑制转录。通过甲状腺受体调节组织对T

Persistent anemia and hypoalbuminemia in rheumatoid arthritis patients with low serum triiodothyronine level复制标题

低血清三碘甲状腺原氨酸水平的类风湿关节炎患者的持续性贫血和低白蛋白血症

发表时间:2019-08-08

影响因子:2.0

作者: Hideaki Tsuji

期刊:MOD RHEUMATOL

Serum triiodothyronine (T3) levels can be decreased in patients with chronic inflammatory conditions, and this finding is called ‘low-T3 syndrome’ or ‘euthyroid sick syndrome’. Generally, T3 is produced by transformation from thyroxine (T4) under normal homeostatic conditions. In low-T3 syndrome, the thyroid gland is normal, but T3 production by conversion from T4 is decreased secondary to suppression of thyrotropin-releasing hormone (TRH) and thyroid-stimulating hormone (TSH) in the presence of inflammation. Rheumatoid arthritis (RA) is an inflammatory disease characterized by joint destruction and physical dysfunction. Serum free T3 (fT3) levels can be decreased in patients with RA, and inflammatory cytokines such as tumor necrosis factor (TNF) or interleukin (IL)-6, key molecules in the pathogenesis of RA, also play important roles in low T3 syndrome. For example, TNF and IL-6 inhibit the conversion of T4 to T3 and inactivate T3. These findings suggest that RA disease activity and serum fT3 levels are closely linked via inflammatory cytokines such as TNF and IL-6. Low serum T3 levels are reported in 7%–52% of RA patients. One of the reasons for the wide-range of frequencies in low-T3 RA patients may be an incomplete definition of ‘low-T3 patients.’ For example, patients with low-T3 caused by autoimmune thyroid diseases (ATD) or those who are taking anti-thyroid medications were included in previous analyses. Furthermore, because of advances in RA treatment, the clinical characteristics of RA patients may have changed. Therefore, the prevalence and characteristics of RA patients with low-T3 levels have not been fully addressed. In this study, we examined fT3, free T4 (fT4), and TSH levels in RA patients. After excluding patients with ATD or those taking anti-thyroid medications, we analyzed the clinical characteristics of RA patients with low-fT3 levels. We also followed patients with low-fT3 levels and compared the clinical characteristics of patients whose fT3 levels normalized with those who showed persistently low-fT3 levels.

译文

患有慢性炎症的患者血清三碘甲状腺原氨酸(T3)水平可降低,这一发现被称为“低T3综合征”或“甲状腺功能正常综合症”。通常,T3在正常稳态条件下通过甲状腺素(T4)的转化产生。在低T3综合征中,甲状腺是正常的,但是在炎症存在下继发于抑制促甲状腺素释放激素(TRH)和促甲状腺激素(TSH)后,通过T4转化产生的T3减少。类风湿性关节炎(RA)是一种以关节破坏和身体功能障碍为特征的炎性疾病。 RA患者血清游离T3(fT3)水平可降低,RA发病机制中的关键分子 - 肿瘤坏死因子(TNF)或白细胞介素(IL)-6等炎性细胞因子在低T3综合征中也起重要作用。 。例如,TNF和IL-6抑制T4向T3的转化并使T3失活。这些发现表明RA疾病活动和血清fT3水平通过炎性细胞因子如TNF和IL-6密切相关。据报道,7%-52%的RA患者血清T3水平较低。低T3 RA患者频率范围广泛的原因之一可能是“低T3患者”的不完全定义。例如,由自身免疫性甲状腺疾病(ATD)引起的低T3患者或那些患者以前的分析包括服用抗甲状腺药物。此外,由于RA治疗的进步,RA患者的临床特征可能已经改变。因此,低T3水平的RA患者的患病率和特征尚未得到充分解决。在这项研究中,我们检查了RA患者的fT3,游离T4(fT4)和TSH水平。排除ATD患者或服用抗甲状腺药物的患者后,我们分析了低fT3水平的RA患者的临床特征。我们还跟踪了低fT3水平的患者,并比较了fT3水平正常化的患者与持续低fT3水平的患者的临床特征。