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Thyroglobulin antibody

内分泌

关键词内分泌 诊断指标 甲状腺蛋白质

词汇介绍

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解析

thyroglobulin   英/,θaɪrə(ʊ)'glɒbjʊlɪn/   美/,θaɪro'ɡlɑbjəlɪn/

释    义   n. [生化] 甲状腺球蛋白

例    句   Objective: To investigate the relations between level of thyroglobulin and thyroid stimulating hormone in pregnant women. 目的:探讨孕妇甲状腺球蛋白水平和促甲状腺素水平之间的关系。

 

antibody   英 /'æntɪbɒdɪ/   美 /'æntɪ'bɑdi/

释    义   n. [免疫] 抗体

例    句   It marshals the same antibody response to both of them. 它对两者作出的抗体反应都是一样的。

概述

甲状腺球蛋白(Tg)是一种660 kDa大小的二聚体的蛋白质,甲状腺球蛋白约占甲状腺蛋白质含量的一半。人TG(HTG)是亚单位的同二聚体,每个亚单位含有合成的2768个氨基酸(短信号肽可以从成熟蛋白的N-末端除去)。功能甲状腺激素合成,甲状腺球蛋白从粗面内质网生产,直到蛋白水解释放甲状腺激素。甲状腺使用Tg来产生甲状腺激素、甲状腺素(T4)和 三碘甲腺原氨酸(T3)。三碘甲腺原氨酸3,5,3'三碘甲腺原氨酸的活性形式在甲状腺内和周围由5'-脱碘酶(其被称为四碘甲腺原氨酸5&#

Time trends of thyroglobulin antibody in ablated papillary thyroid carcinoma patients: Can we predict the rate of negative conversion?复制标题

消融甲状腺乳头状癌患者甲状腺球蛋白抗体的时间趋势: 我们能预测转阴率吗?

发表时间:2019-04-12

影响因子:3.7

作者: Eyun Songa

期刊:Oral Oncology

Persistence of thyroglobulin antibody (TgAb) during follow-up in patients with differentiated thyroid carcinoma (DTC) after complete removal of the thyroid tissue is a challenge for clinicians since TgAb can interfere with thyroglobulin (Tg) measurement which is the most sensitive marker for remnant thyroid. TgAb is present in 17%–25% of patients with DTC and is an important factor for assessing the dynamic risk stratification, as proposed by Tuttle et al. and adopted by the guidelines of the American Thyroid Association. According to this classification, patients with DTC who underwent total thyroidectomy (TT) followed by radioiodine (RAI) ablation and are positive for TgAb exhibit prognoses similar to those observed between the “excellent response” and “structural incomplete response” groups. However, long-term data regarding the natural course of TgAb titers in these patients (i.e., the disappearance of TgAb and factors affecting the timing of negative conversion) are limited. Previous studies have reported that a median of 2–3 years is required for negative conversion of TgAb. The thyroid gland is the only source of Tg and TgAbs are mostly produced by lymphocytes infiltrating the gland; therefore, complete elimination of the thyroid tissue by TT and subsequent RAI ablation of the remnant thyroid tissue results in a progressive decline in TgAb levels and eventually its disappearance. However, certain patients may remain positive for TgAb years after ablation even in the absence of evidence of structural disease (no evidence of structural disease, NESD). There are evidences that increased or stationary TgAb titers may be associated with persistence/recurrence of thyroid cancer. However, there is no consensus on whether or when to performe extensive and/or frequent imaging investigations to detect evidence for structural disease in patients persistently positive for TgAb during follow-up. To clarify this issue, the present study evaluated the time trends of TgAb in patients with papillary thyroid carcinoma (PTC) and NESD, who previously underwent TT and subsequent RAI ablation and aimed to identify predictive factors for the rate of negative conversion of TgAb.

译文

完全切除甲状腺组织后,分化型甲状腺癌(DTC)患者随访期间甲状腺球蛋白抗体(TgAb)的持续存在对临床医生来说是一个挑战,因为TgAb可以干扰甲状腺球蛋白(Tg)测量,这是残留物最敏感的标志物。甲状腺。如Tuttle等人提出的,TgAb存在于17%-25%的DTC患者中,并且是评估动态危险分层的重要因素。并被美国甲状腺协会的指导所采纳。根据该分类,接受全甲状腺切除术(TT)随后放射性碘(RAI)消融并且TgAb阳性的DTC患者表现出类似于“优异反应”和“结构不完全反应”组之间观察到的预后。然而,关于这些患者中TgAb滴度的自然过程的长期数据(即TgAb的消失和影响负转化时间的因素)是有限的。以前的研究报道,TgAb的负转化需要2  -  3年的中位数。甲状腺是Tg的唯一来源,TgAb主要由浸润腺体的淋巴细胞产生;因此,通过TT完全消除甲状腺组织并随后对残余甲状腺组织进行RAI消融导致TgAb水平逐渐下降并最终消失。然而,即使没有结构性疾病的证据(没有结构性疾病的证据,NESD),某些患者在消融后可能仍然保持TgAb阳性。有证据表明TgAb滴度升高或静止可能与甲状腺癌的持续/复发有关。然而,对于是否或何时进行广泛和/或频繁的成像研究以检测在随访期间TgAb持续阳性的患者的结构性疾病的证据尚无共识。为了澄清这个问题,本研究评估了乳头状甲状腺癌(PTC)和NESD患者TgAb的时间趋势,这些患者之前接受了TT和随后的RAI消融,旨在确定TgAb阴性转换率的预测因素。