微信扫码关注“小狗文献”

即刻体验更多权益

文献多,下载快,翻译准

首页 > 医学词汇大全 > Thyroid peroxidase antibody
Thyroid peroxidase antibody

内分泌

关键词内分泌 疾病 甲状腺表达酶

词汇介绍

拓展阅读

解析

thyroid   英 /'θaɪrɒɪd/   美 /'θaɪrɔɪd/

释    义   n. 甲状腺;甲状软骨;甲状腺剂

adj. 甲状腺的;盾状的

例    句   Objective To study the correlation between expression of CD105 and lymph node metastasis in thyroid carcinoma tissue. 目的研究甲状腺癌组织中CD105的表达意义及与淋巴结转移的相关性。

 

peroxidase   英 /pə'rɒksɪdeɪz/   美 /pə'rɑksɪ,des; pə'rɑksɪ,dez/

释    义   n. [生化] 过氧物酶

例    句   Glutathione peroxidase is a typical non metallic enzyme, it can inhibit the generation of free radicals. 谷胱甘肽过氧化物酶是典型的非金属酶,它具有抑制自由基生成。

 

antibody  英 /'æntɪbɒdɪ/   美 /'æntɪ'bɑdi/

释    义   n. [免疫] 抗体

例    句   Each antibody in this kit recognizes only its specific target and does not cross-react with other family members. 在这个试剂盒中的每个抗体只识别其特异靶标蛋白,不与其他家族成员交叉反应。

概述

甲状腺过氧化物酶,也称为甲状腺过氧化物酶(TPO)或碘化过氧化物酶,是一种酶主要表达在甲状腺,在甲状腺中它被分泌到胶体里。甲状腺过氧化物酶氧化碘离子以形成碘用于添加到原子酪氨酸上的残留物甲状腺球蛋白生产的甲状腺素(T4)或三碘甲状腺氨酸(T3)时。在人类中,甲状腺过氧化物酶由TPO 基因编码。功能甲状腺激素合成,甲状腺过氧化物酶进行氧化步骤,无机碘主要以碘化物的形式进入人体,在基底侧通过Na + / I -同向转运体(NIS)进入甲状腺滤泡(或甲状腺滤泡细胞)后,碘化物通过pendrin穿过

Thyroid peroxidase antibodies and prospective live birth - a cohort study of women with recurrent pregnancy loss复制标题

甲状腺过氧化物酶抗体与前瞻性活产 -- 复发性流产妇女的队列研究

发表时间:2019-08-13

影响因子:7.8

作者: Sofie Bliddal

期刊:Thyroid

Pregnancy loss is the most common pregnancy complication occurring in more than 25% of all wanted pregnancies. A subset of women experiences recurrent pregnancy loss defined as a minimum of three consecutive pregnancy losses or two pregnancy losses in the second trimester or later. It is a physically and psychologically challenging condition associated with reduced quality of life, depression, and comorbidities later in life. An explanation for the condition is only found in approximately 40% of investigated cases (including risk factors such as parental chromosomal abnormalities, uterine malformations, or antiphospholipid syndrome), while the remaining cases are categorized as unexplained recurrent pregnancy losses. Thyroid autoimmunity has been associated with reproductive challenges such as infertility, pregnancy loss, and preterm delivery. In women of reproductive age, thyroid autoimmunity is the most common autoimmune disturbance. In previously thyroid‐healthy Danish pregnant women, we have shown a prevalence of thyroid antibody‐positivity (thyroid peroxidase and/or thyroglobulin antibodies ≥60 kU/L) of 16.1%, in accordance with findings in the background population. In a meta‐analysis by Thangaratinam et al., 6‐20% of women of reproductive age were thyroid antibody‐positive, while the prevalence increased to 17‐33% in women with recurrent pregnancy loss and 10‐31% in subfertile women. In 1990, Stagnaro‐Green et al. found a miscarriage rate of 17% in thyroid antibody‐positive women compared to 8.4% in thyroid antibody‐negative women (p<0.05). Many studies have since confirmed this association, while others have questioned the association between thyroid antibodies and reproductive failure. Despite discrepancies and lack of evidence from randomized controlled trials, international guidelines recommend screening for thyroid antibodies in women with reproductive failure, including those with recurrent pregnancy loss, and a lenient attitude towards thyroxine replacement (T4) treatment in case of TPOAb‐positivity (i.e. considering treatment at TSH concentrations >2.5 mIU/L).

译文

妊娠丢失是超过25%的所有怀孕期间发生的最常见的妊娠并发症。一部分女性经历了复发性妊娠丢失,定义为妊娠中期或之后至少连续三次妊娠丢失或两次妊娠丢失。这是一种身体和心理上具有挑战性的疾病,与生命后期生活质量下降,抑郁和合并症有关。只有大约40%的被调查病例(包括父母染色体异常,子宫畸形或抗磷脂综合征等危险因素)才能找到该病症的解释,而其余病例则归类为不明原因的复发性妊娠损失。甲状腺自身免疫与生育挑战有关,如不孕,妊娠丢失和早产。在育龄妇女中,甲状腺自身免疫是最常见的自身免疫性疾病。在先前甲状腺健康的丹麦孕妇中,根据背景人群的调查结果,我们发现甲状腺抗体阳性(甲状腺过氧化物酶和/或甲状腺球蛋白抗体≥60kU/ L)的患病率为16.1%。在Thangaratinam等人的荟萃分析中,6-20%的育龄妇女是甲状腺抗体阳性,而复发性妊娠妇女的患病率增加到17-33%,不孕妇女的患病率增加到10-31%。 1990年,Stagnaro-Green等人。发现甲状腺抗体阳性女性的流产率为17%,而甲状腺抗体阴性女性为8.4%(p <0.05)。许多研究已证实这种关联,而其他研究则质疑甲状腺抗体与生殖障碍之间的关系。尽管随机对照试验存在差异和缺乏证据,但国际指南建议筛查生殖障碍妇女的甲状腺抗体,包括那些复发性妊娠丢失的患者,以及在TPOAb阳性的情况下对甲状腺素替代(T4)治疗的宽容态度(即考虑在TSH浓度> 2.5 mIU / L时的治疗。