微信扫码关注“小狗文献”

即刻体验更多权益

文献多,下载快,翻译准

首页 > 医学词汇大全 > Graves disease
Graves disease

内分泌

关键词内分泌 疾病 自身免疫性疾病

词汇介绍

拓展阅读

解析

Graves   英 /ɡreivz/

释    义   n. (法国)格拉夫葡萄酒

例    句   Most people go to their graves, with music still in them. ------ Oliver Wendell Holmes. 多数人走入坟墓,音乐还仍在他们心中。------奥利弗.文达.豪迈斯。

 

disease   英 /dɪ'ziːz/   美 /dɪ'ziz/

释    义   n. 病,[医] 疾病;弊病

               vt. 传染;使…有病

同根词   diseased adj. 不健全的;患病的;病态的

               diseased v. 使生病;传染(disease的过去分词)

例    句   So 9% less cardiovascular disease, 13% less Parkinson's and Alzheimer's, 6% less cancer, 9% less mortality from all causes. 心血管类疾病患病率降低9%,帕金森病和老年痴呆症降低13%,癌症降低6%,由各种原因导致的死亡率降低9%。

概述

格雷夫斯病,又称慢性毒性弥漫性甲状腺肿,是一种影响甲状腺的自身免疫性疾病。它是甲状腺功能亢进的最常见原因,也经常导致甲状腺肿大。甲亢的症状和体征可能包括烦躁,肌肉无力,睡眠问题,心跳加快,耐热性差,腹泻和无意识的体重减轻。其他症状可能包括胫骨皮肤增厚,称为胫前粘液性水肿和眼球膨出,这是格雷夫斯眼病引起的特征性疾病。临床特征格雷夫斯病临床上可能存在以下一种或多种特征:心动过速(80%);弥漫性可触及的甲状腺肿(70%);震颤(40%);眼球突出(单眼或双眼的突起)、眶周水肿(25%);疲劳(7

Increased Remission Rates After Long-Term Methimazole Therapy in Patients with Graves' Disease: Results of a Randomized Clinical Trial复制标题

Graves病患者长期接受甲巯咪唑治疗后缓解率增加: 一项随机临床试验的结果

发表时间:2019-08-28

影响因子:7.8

作者: Fereidoun Azizi

期刊:Thyroid

Over the last 70 years, millions of patients with Graves’ hyperthyroidism were effectively treated with thionamide antithyroid drugs (ATDs). However, these treatments have an important drawback: high recurrence rates, estimated at 51 to 68% in one systematic review. Surprisingly given the drugs’ longstanding widespread use, the optimal duration of ATD therapy to minimize relapse frequency remains unclear. Historically, the approximately 30 to 40% remission rate attained with 12‐18month courses of therapy and this duration has been considered the upper limit of the duration of treatment. However, a few studies and a recent meta‐analysis suggested that longer‐term ATD treatment of hyperthyroidism may be associated with higher remission rates, with a low frequency of drug‐related complications. Resolving how long to give ATDs has been hampered by the generally small sample sizes and sometimes short follow‐up of studies examining the question. We therefore conducted a trial with a relatively large sample size and longitudinal surveillance for several years to compare rates of remission of hyperthyroidism in patients with longer‐term versus conventional ATD therapy. We also sought to identify those patients receiving conventional therapy who might be high priority candidates for longer ATD treatments by determining variables associated with relapse in such individuals.  In view of the importance of genotype and HLA subtypes in predicting relapse of hyperthyroidism, we have added these variables to clinical and demographic factors to address this important aspect.

译文

在过去的70年中,数百万Graves'甲状腺功能亢进症患者使用硫脲类抗甲状腺药物(ATDs)进行了有效治疗。然而,这些治疗有一个重要的缺点:高复发率,在一项系统评价中估计为51%至68%。令人惊讶的是,鉴于药物的长期广泛使用,ATD治疗最小化复发频率的最佳持续时间仍不清楚。从历史上看,在12-18个疗程的疗程中达到约30%至40%的缓解率,并且该持续时间被认为是治疗持续时间的上限。然而,一些研究和最近的一项荟萃分析表明甲状腺功能亢进的长期ATD治疗可能与更高的缓解率相关,并且药物相关并发症的发生率较低。通过较小的样本量以及有时对研究该问题的研究进行短期跟踪,阻碍了给予ATD的时间长短受到阻碍。因此,我们进行了一项具有相对较大样本量和纵向监测数年的试验,以比较长期患者与常规ATD治疗患者甲状腺功能亢进症的缓解率。我们还试图通过确定与这些个体复发相关的变量来识别接受常规治疗的患者,这些患者可能是更长时间ATD治疗的高优先级候选者。鉴于基因型和HLA亚型在预测甲状腺功能亢进症复发中的重要性,我们已将这些变量添加到临床和人口统计学因素中以解决这一重要方面。