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首页 > 医学词汇大全 > Zucker Diabetic Fatty rats
Zucker Diabetic Fatty rats

内分泌

关键词内分泌 实验材料 糖尿病基础研究

词汇介绍

拓展阅读

解析

Zucker

释    义   n. (Zucker)人名;(捷)祖克尔;(德)楚克尔;(英)朱克

例    句   "A major objective is for countries to agree that counterfeiting is a crime against human security and incorporate that principle into their laws," added Dr Zucker. Zucker博士还说,“一项主要目标是,使各国同意造假是危害人类安全的一大罪行,并将该原则写入法律”。

 

diabetic   英 /daɪə'betɪk/   美 /,daɪə'bɛtɪk/

释    义   adj. 糖尿病的,患糖尿病的

               n. 糖尿病患者

例    句   Diabetic kidney disease can be prevented by keeping blood sugar in your target range. 糖尿病肾病可以通过保持血糖在你的目标范围内来预防。

 

fatty   英 /'fætɪ/   美 /'fæti/

释    义   adj. 脂肪的;肥胖的;多脂肪的;脂肪过多的

               n. 胖子

例    句   Cholesterol is a fatty substance in your blood. 在你的血液里胆固醇是一种脂肪物质。

 

rats   英 /ræts/   美 /ræts/

释    义   int. 胡说;瞎扯

               n. [脊椎] 鼠;卑鄙之人(rat的复数)

               v. 捕鼠;出卖(rat的三单形式)

例    句   Rats traveled with people to every corner of the Pacific. 老鼠跟随人类到达太平洋每个角落。

概述

肥胖II型糖尿病大鼠(ZDF大鼠)是在肥胖型Zucker大鼠中发现的能够发展成严重的II型糖尿病的大鼠,除了出现糖尿病表现,还包括胰岛素抵抗,高血脂以及发展为各种并发症。特点ZDF大鼠具备肥胖型Zucker大鼠的大多数特点,包括肥胖、胰岛素抵抗、糖耐量试验异常、高胰岛素血症、高瘦素血症、高血脂。还有如下特点:①雄性发生II型糖尿病,空腹血糖升高,而雌性没有空腹血糖升高。雄性ZDF在6~7周龄时开始肥胖,7~10周龄时血糖可达400~500 mg/dL,10~12周龄血糖稳步升高,而在血浆胰岛

Detailed Evaluation of Possible Ganglion Cell Loss in the Retina of Zucker Diabetic Fatty (ZDF) Rats复制标题

Zucker糖尿病脂肪 (ZDF) 大鼠视网膜中可能的神经节细胞丢失的详细评价

发表时间:2019-07-18

影响因子:4.0

作者: Rozina I Hajdul

期刊:SCI REP

Animal and human studies congruently suggest that both neural and vascular elements of the retina are damaged by the diabetic environment. Neural and vascular retinal tissue are damaged as a complex unit: alterations in early diabetes (preceding clinically manifest vasculopathy) include changes of certain characteristics of neural cell types including morphology, number, neurotransmission, synapses, as well as subclinical vascular changes. Amongst neural cell types the involvement of photoreceptor cells, horizontal, amacrine and retinal ganglion cell types has been documented. It is still obscure though how the neurodegeneration and vasculopathy are related to each other, whether or not the vascular of neural changes trigger each other. Tere is a general agreement, however, that damaged cells – both neurons and vascular cells - will eventually die, leading to a progressive cell loss in diabetes. Apoptotic loss of neural as well as vascular elements has been reported in many diferent animal models. Furthermore, postmortem human samples and in vivo OCT data show evidence that progressive cell death may eventually lead to the thinning of the retinal layers. Specifcally, the inner retinal layers and ganglion cells are thought to be the most vulnerable. According to some human OCT data, loss of ganglion cells may be the frst morphological sign of diabetes, preceding clinically detectable vasculopathy or even present in metabolic syndrome. With the recent introduction of OCT Angiography (OCTA) it is possible assess the in vivo capillary structure of the macula. It seems that the microvascular and retinal changes are coexisting and appear to be well detectable.

译文

动物和人类研究一致表明视网膜的神经和血管元素都被糖尿病环境破坏。神经和血管视网膜组织作为一个复杂的单位受到损害:早期糖尿病(临床上明显的血管病变之前)的改变包括神经细胞类型的某些特征的变化,包括形态,数量,神经传递,突触以及亚临床血管变化。在神经细胞类型中,已经记载了感光细胞,水平,无长突和视网膜神经节细胞类型的参与。尽管神经变性和血管病变如何相互关联,神经变化的血管是否相互触发仍然是模糊的。然而,Tere是一个普遍的协议,受损细胞 - 神经元和血管细胞 - 最终会死亡,导致糖尿病进行性细胞损失。在许多不同的动物模型中已经报道了神经元和血管元件的凋亡丧失。此外,死后人类样本和体内OCT数据显示进行性细胞死亡最终可能导致视网膜层变薄的证据。特别地,内视网膜层和神经节细胞被认为是最脆弱的。根据一些人类OCT数据,神经节细胞的损失可能是糖尿病的第一个形态学征象,在临床可检测的血管病变之前或甚至存在于代谢综合征中。随着最近引入的OCT血管造影术(OCTA),可以评估黄斑的体内毛细血管结构。似乎微血管和视网膜的变化是共存的,并且似乎可以很好地检测到。