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首页 > 医学词汇大全 > Oral glucose tolerance test
Oral glucose tolerance test

内分泌

关键词内分泌 实验技术 糖尿病诊断

词汇介绍

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解析

oral   英 /'ɔːr(ə)l/   美 /'ɔrəl/

释    义   adj. 口头的,口述的

               n. 口试

同根词   orally adv. 口头上地;口述地

例    句   If there is an infection, your child may need a course of oral antibiotics. 如果有感染,您的孩子可能需要一个疗程的口服抗生素。

 

glucose    英 /'gluːkəʊs; -z/   美 /'ɡlukos/

释    义   n. 葡萄糖;葡糖(等于dextrose)

例    句   Identifying the presence of brown fat is one thing, but activating it to burn more glucose is another. 确定棕色脂肪的存在是一回事,但激活它让它燃烧更多葡萄糖是另一回事。

 

tolerance   英/'tɒl(ə)r(ə)ns/   美/'tɑlərəns/

释    义   n. 公差;宽容;容忍

同根词   tolerant adj. 宽容的;容忍的;有耐药力的

               tolerably adv. 相当地;可容忍地;差不多地

               toleration n. 宽容,忍受,默认;耐受性

               tolerate vt. 忍受;默许;宽恕

例    句   The integrity of the life, is forgiveness, tolerance, waiting with love, if not all of this, you have all, is nothing. 生命的完整,在于宽恕、容忍、等待与爱,如果没有这一切,你拥有了所有,也是虚无。

 

test   英/test/

释    义   n. 测验,考查;测试;检验;化验

               v. 测验;化验,检查;试验,测试;考验

例    句   My doctor wants me to be tested for diabetes. 我的医生要我去做糖尿病检查。

概述

葡萄糖耐量试验,也称为口服葡萄糖耐量试验,主要是测量患者身体对糖(葡萄糖)的反应。葡萄糖耐量试验可用于筛查2型糖尿病。更常见的是,葡萄糖耐量试验的改良版本可用于诊断妊娠期糖尿病-1种在怀孕期间发展的糖尿病。葡萄糖耐量试验可确定患者的身体在饭后处理葡萄糖的方式是否异常-通常在患者的空腹血糖水平出现异常之前。测试前准备在葡萄糖耐量试验前的日子里,正常进食和饮水很重要。在测试前八小时,应在前一夜禁食,并在第二天早上安排测试。葡萄糖耐量试验将分几步完成,医疗团队成员将从患者手臂的静脉取血样。该血液样

Oral dehydroepiandrosterone restores β-endorphin response to OGTT in early and late Postmenopause复制标题

口服脱氢表雄酮在绝经后早期和晚期恢复 β-内啡肽对OGTT的反应

发表时间:2019-09-01

影响因子:1.4

作者: A Giannini

期刊:Gynecol Endocrinol

Menopause represents a peculiar moment of women’s life. After 70 years of age, dehydroepiandrosterone [DHEA(S)] levels are 20% or less of the maximum plasma concentrations. It has been hypothesized that during the aging process, the reduction of 17,20 desmolase activity, the enzyme that rules the biosynthesis of the D5-adrenal pathway, may induce modifications in DHEA(S) synthesis. Growing evidence in literature support the hypothesis that lower levels of DHEA occurring during aging have been associated with impaired glucose tolerance, insulin resistance, and diabetes. Moreover, recent data demonstrated that DHEA administration greatly improves most of menopausal symptoms and endocrine impairments acting on each tissue and organ through an intracrinological effect since this molecule acts as a sort of pre-hormone for the production of active metabolites. DHEA administration is not yet considered a medical treatment though this steroid has been demonstrated to induce specific metabolic effects and to counteract the age-induced changes at the adrenal gland level as well as to increase anxiolytic substances (allopregnanolone) and some neuropeptides (i.e. b-endorphin). ß-endorphin is the most important and biologically active endogenous neuropeptide involved in several brain functions. Previous studies have demonstrated high plasma ß-endorphin levels in obese subjects and that ß-endorphin release is induced after an oral glucose tolerance test (OGTT) both in normal and in obese women  Interestingly, when post-menopausal women with normal Body Mass Index (BMI) underwent an OGTT, they lack the ability to increase plasma circulating ß-endorphin under the glucose load since a specific modulation of the opioidergic system due to sex steroid hormone balance has been proposed to modify ß-endorphin response and response to metabolic stimuli, such as glucose load.

译文

更年期代表了女性生命中一个特殊的时刻。 70岁以后,脱氢表雄酮[DHEA(S)]水平为最大血浆浓度的20%或更低。已经假设在衰老过程中,17,20去氨激酶活性的减少,即控制D5-肾上腺途径生物合成的酶,可以诱导DHEA(S)合成中的修饰。文献中越来越多的证据支持这样的假设,即衰老过程中出现较低水平的DHEA与葡萄糖耐量降低,胰岛素抵抗和糖尿病有关。此外,最近的数据表明,DHEA给药通过内部细胞学作用大大改善了作用于每个组织和器官的大多数绝经期症状和内分泌损伤,因为该分子充当活性代谢物产生的一种前激素。 DHEA给药尚未被认为是一种药物治疗,尽管已证明该类固醇可诱导特定的代谢作用并抵消年龄诱导的肾上腺水平变化以及增加抗焦虑物质(allopregnanolone)和一些神经肽(即b-内啡肽)。 β-内啡肽是参与多种脑功能的最重要且具有生物活性的内源性神经肽。以前的研究表明肥胖受试者的血浆β-内啡肽水平较高,并且在正常和肥胖女性口服葡萄糖耐量试验(OGTT)后都会诱发β-内啡肽释放。有趣的是,当绝经后妇女体重指数正常时( BMI)经历了OGTT,他们缺乏在葡萄糖负荷下增加血浆循环β-内啡肽的能力,因为已经提出由于性类固醇激素平衡而对阿片类药物系统进行特定调节以改变β-内啡肽反应和对代谢刺激的反应,如葡萄糖负荷。