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首页 > 医学词汇大全 > Hemoglobin A1c
Hemoglobin A1c

内分泌

关键词内分泌 临床研究术语 血浆葡萄糖浓度检测

词汇介绍

拓展阅读

解析

hemoglobin   英/,hiːməʊ'ɡləʊbɪn/   美/,hɛmo'ɡlobɪn/

释    义   n. [生化] 血红蛋白(等于haemoglobin);血红素

同根词   hemoglobinopathy n. [内科] 血红蛋白病(等于haemoglobinopathy)

例    句   Some, like hemoglobin, deliver oxygen from the lungs to the far reaches of the body. 有些蛋白质像血红蛋白一样,可以把氧从肺部输送到身体各处。

概述

糖化血红蛋白(HbA1c)是血红蛋白的一种形式,其主要用于鉴定3个月平均血浆葡萄糖浓度。该测试仅限于3个月的平均值,因为红细胞的寿命为四个月。它通过血红蛋白暴露于血浆葡萄糖而在非酶糖化途径中形成。是血红蛋白β-N-1-脱氧果糖基组分的量度。正常水平的葡萄糖产生正常量的糖化血红蛋白。原理蛋白质的糖化经常发生,但在血红蛋白的情况下,葡萄糖和β链的N-末端之间发生非酶促反应,这形成席夫碱,其本身转化为1-脱氧果糖。当血糖水平高时,葡萄糖分子附着在红细胞中的血红蛋白上。血液中发生较长的高血糖,红细胞

Trajectories of hemoglobin A1c and BMI z-score over four decades among 2-18 year olds with type 1 diabetes复制标题

2-18岁1型糖尿病患者40年血红蛋白A1c和BMI z评分的轨迹

发表时间:2019-08-10

影响因子:3.3

作者: Jaime M Moore

期刊:Pediatric Diabetes

Most children and adolescents with T1D in the United States (US) do not meet the recommended HbA1c target of <7.5% (58mmol/mol), which increases their risk of developing diabetes-related complications. Recent studies have reported that girls with T1D have worse metabolic control and complications than boys with T1D, and higher BMI z-scores than boys with T1D and girls without T1D. Women with T1D have a significantly higher relative risk of cardiovascular disease (CVD) compared to men with T1D, when each are compared to their non-diabetic counterparts. What remains poorly understood is when this divergence in risk by sex begins and what is driving it.But data suggest that adolescence may be a critical time period during which sex differences in CVD risk factors emerge, particularly glycemic control and obesity. Deterioration of glycemic control for youth with T1D during adolescence has been frequently reported, and potential contributors to poor glucose control during puberty include a physiologic decrease in insulin sensitivity, increased autonomy in diabetes management, and psychosocial changes. However, the premise that all adolescents will experience worsened glycemic control is an imprecise over generalization, and may contribute to missed opportunities to identify and treat the highest-risk youth. Several studies have used longitudinal group-based modeling to identify subgroups of children with T1D that follow distinct trajectories of glycemic control during adolescence, and all have, surprisingly, reported that only the minority of young people with T1D experience deteriorating glycemic control during adolescence.

译文

在美国(美国),大多数患有T1D的儿童和青少年不符合推荐的<7.5%(58mmol / mol)的HbA1c目标,这增加了患糖尿病相关并发症的风险。最近的研究报道,T1D女孩的代谢控制和并发症比T1D男孩更差,BMI z分数高于T1D男孩和没有T1D的女孩。与患有T1D的男性相比,患有T1D的女性患心血管疾病(CVD)的相对风险显着高于非糖尿病患者。仍然知之甚少的是,这种性别风险差异何时开始,以及是什么驱使它。但数据显示,青春期可能是心血管疾病危险因素的性别差异出现的关键时期,特别是血糖控制和肥胖。青春期T1D青年血糖控制的恶化经常被报道,青春期血糖控制不良的潜在因素包括胰岛素敏感性的生理性降低,糖尿病管理的自主性增加和社会心理变化。然而,所有青少年都会经历恶化血糖控制的前提是对概括的不精确,并可能导致错失识别和治疗风险最高的青少年的机会。一些研究使用纵向基于组的模型来识别T1D儿童亚组,这些儿童在青春期期间遵循不同的血糖控制轨迹,并且令人惊讶地报告说,只有少数患有T1D的年轻人在青春期经历恶化的血糖控制。