l eptin 英 /'lɛp,tɪn/
释 义 n. （脂肪组织产生的）瘦蛋白
例 句 The virus also increases lipid sensitivity and decreases leptin secretion of the new fat cells. 该病毒还会增加新脂肪细胞的脂肪灵敏度，并降低其瘦素分泌。
作者： Sandra K Boppa
Lithium augmentation (LA) is an effective strategy in the treatment of major depressive disorder (MDD). Weight gain is a common adverse effect of lithium treatment that occurs in 25%−62% of patients. Weight gain leads to obesity, increases the risk of developing metabolic disorders and is a serious reason for treatment interruption and a decreased quality of life. Leptin, an anorexigenic protein hormone, is primarily secreted by white adipose tissue. Through its hypothalamic receptor, leptin seems to influence several biological functions involved in the pathophysiology of obesity. It decreases body weight by both suppressing appetite and increasing energy expenditure. Different polymorphisms in the leptin gene (LEP) are discussed to be involved in obesity, weight gain, and metabolic diseases. Over the past years, numerous studies were undertaken to discover genetic variants that may be involved in weight gain triggered by psychopharmacological treatment. However, the majority of studies focused on antipsychotic-induced weight gain (AIWG). Research on LEP polymorphisms focused mainly on rs7799039 (−2548 G/A) and produced inconsistent results, although several studies found an association of the G allele of rs7799039 with AIWG. A small number of studies also analyzed other polymorphisms in LEP, e.g. rs4731426 and rs10954173, and reported an association with AIWG.We found only 1 earlier study that explored polymorphisms in genes and their influence on weight gain during lithium treatment. This study found no association between polymorphisms in the alpha-subunit of the G(olf) gene and weight gain in 149 bipolar patients on lithium treatment. In a previous study, we found an effect of leptin serum levels on weight gain during LA. Genotype-dependent effects on leptin serum levels are described in the literature. On the basis of these previous findings and the pharmacogenetic knowledge gap regarding lithium-induced weight gain, we investigated in a prospective cohort study the effect of polymorphisms in LEP on body mass index (BMI) and leptin serum levels during LA. The primary aim of our study was to identify polymorphisms in LEP that are associated with lithium-induced weight gain. The secondary aim was to investigate whether these variants modulate serum leptin levels.