微信扫码关注“小狗文献”

即刻体验更多权益

文献多,下载快,翻译准

Leptin

内分泌

关键词内分泌 临床研究术语 调节能量平衡

词汇介绍

拓展阅读

解析

l eptin   英 /'lɛp,tɪn/

释    义   n. (脂肪组织产生的)瘦蛋白

例    句   The virus also increases lipid sensitivity and decreases leptin secretion of the new fat cells. 该病毒还会增加新脂肪细胞的脂肪灵敏度,并降低其瘦素分泌。

概述

Leptin是一种主要由脂肪细胞和小肠中的肠细胞制成的激素,它通过抑制饥饿来调节能量平衡,从而减少脂肪细胞中的脂肪储存。瘦素作用于下丘脑弓状细胞核中的细胞受体。虽然脂肪储存的调节被认为是瘦素的主要功能,但它也在其他生理过程中发挥作用,正如其脂肪细胞以外的许多合成位点以及具有瘦素受体的下丘脑细胞以外的许多细胞类型所证明。在肥胖症中,对瘦素的敏感性降低(类似于2型糖尿病中的胰岛素抵抗),尽管存在高能量储存和高水平的瘦素但仍无法检测饱腹感。在肥胖中的作用尽管瘦素会降低食欲作为循环信号,但肥胖个体通

Leptin gene polymorphisms are associated with weight gain during lithium augmentation in patients with major depression复制标题

瘦素基因多态性与重性抑郁症患者锂增加过程中体重增加相关

发表时间:2018-12-13

影响因子:4.5

作者: Sandra K Boppa

期刊:EUR NEUROPSYCHOPHARM

Lithium augmentation (LA) is an effective strategy in the treatment of major depressive disorder (MDD). Weight gain is a common adverse effect of lithium treatment that occurs in 25%−62% of patients. Weight gain leads to obesity, increases the risk of developing metabolic disorders and is a serious reason for treatment interruption and a decreased quality of life. Leptin, an anorexigenic protein hormone, is primarily secreted by white adipose tissue. Through its hypothalamic receptor, leptin seems to influence several biological functions involved in the pathophysiology of obesity. It decreases body weight by both suppressing appetite and increasing energy expenditure. Different polymorphisms in the leptin gene (LEP) are discussed to be involved in obesity, weight gain, and metabolic diseases. Over the past years, numerous studies were undertaken to discover genetic variants that may be involved in weight gain triggered by psychopharmacological treatment. However, the majority of studies focused on antipsychotic-induced weight gain (AIWG). Research on LEP polymorphisms focused mainly on rs7799039 (−2548 G/A) and produced inconsistent results, although several studies found an association of the G allele of rs7799039 with AIWG. A small number of studies also analyzed other polymorphisms in LEP, e.g. rs4731426 and rs10954173, and reported an association with AIWG.We found only 1 earlier study that explored polymorphisms in genes and their influence on weight gain during lithium treatment. This study found no association between polymorphisms in the alpha-subunit of the G(olf) gene and weight gain in 149 bipolar patients on lithium treatment. In a previous study, we found an effect of leptin serum levels on weight gain during LA. Genotype-dependent effects on leptin serum levels are described in the literature. On the basis of these previous findings and the pharmacogenetic knowledge gap regarding lithium-induced weight gain, we investigated in a prospective cohort study the effect of polymorphisms in LEP on body mass index (BMI) and leptin serum levels during LA. The primary aim of our study was to identify polymorphisms in LEP that are associated with lithium-induced weight gain. The secondary aim was to investigate whether these variants modulate serum leptin levels.

译文

锂增强(LA)是治疗重度抑郁症(MDD)的有效策略。体重增加是锂治疗的常见不良反应,发生在25%-62%的患者中。体重增加导致肥胖,增加发生代谢紊乱的风险,并且是治疗中断和降低生活质量的严重原因。瘦素是一种食欲减退的蛋白质激素,主要由白色脂肪组织分泌。通过其下丘脑受体,瘦素似乎影响肥胖病理生理学中涉及的几种生物学功能。它通过抑制食欲和增加能量消耗来减轻体重。瘦素基因(LEP)中的不同多态性被讨论与肥胖,体重增加和代谢疾病有关。在过去几年中,进行了大量研究以发现可能与精神药理学治疗引发的体重增加有关的遗传变异。然而,大多数研究集中于抗精神病药物诱导的体重增加(AIWG)。对LEP多态性的研究主要集中在rs7799039(-2548 G / A)并产生不一致的结果,尽管一些研究发现rs7799039的G等位基因与AIWG有关。少数研究还分析了LEP中的其他多态性,例如rs4731426和rs10954173,并报告了与AIWG的关联。我们发现只有1个早期的研究探索了基因的多态性及其对锂处理过程中体重增加的影响。该研究发现,G(olf)基因的α亚基中的多态性与149名双极患者在锂治疗中的体重增加之间没有关联。在先前的研究中,我们发现瘦素血清水平对LA期间体重增加的影响。瘦素血清水平的基因型依赖性作用描述于文献中。基于这些先前的发现和关于锂诱导的体重增加的药物遗传学知识差异,我们在一项前瞻性队列研究中研究了LEP中多态性对LA期间体重指数(BMI)和瘦素血清水平的影响。我们研究的主要目的是鉴定LEP中与锂诱导的体重增加相关的多态性。次要目的是研究这些变体是否调节血清瘦素水平。