Phosphorylation 英 /fɔ,sfɔri'leiʃən/
释 义 n. [有化] 磷酸化作用
例 句 What still needs to be explained is how the more typical eukaryotic phosphorylation cascades evolved and came to replace the bacterial systems.我们仍然需要解释的是更特化的真核生物的磷酸化途径是怎么进化而来并取代了细菌的系统。
作者： Byung-Kwon Choi
To preserve genomic integrity, systems of DNA damage detection, response, and repair have evolved. Key components of the DNA damage response (DDR) system include a set of kinases that recognize damage and transduce signals that activate the many cellular responses to DNA damage. The phosphatidylinositol 3-kinase-like kinase (PIKK) family, typified by the intensively studied ATM, ATR, and DNA-PK, play a central role in the DDR. These kinases are activated almost immediately following DNA damage and transduce their damage response signal through phosphorylation of DDR target proteins.