Pulsed glucocorticoids enhance dystrophic muscle performance through epigenetic metabolic reprogramming复制标题

脉冲糖皮质激素通过表观遗传代谢重编程增强营养不良肌肉性能

Tightly regulated control of muscle metabolism is essential to performance and the well being of the whole organism. With exercise, muscle coordinately upregulates the metabolism of glucose, fatty acids, and amino acids for energy production, and this response varies with time of day. In Duchenne Muscular Dystrophy (DMD), loss of dystrophin produces a fragile muscle membrane, leading to muscle degeneration. In addition to the primary loss of dystrophin, muscle mitochondrial function and ATP synthetic capacity are secondarily impaired. Glucocorticoid (GC) steroids are used in DMD, where their use prolongs ambulation.

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