内分泌
词汇介绍
拓展阅读
解析
histone 英 /'hɪstəʊn/ 美 /'hɪston/
释 义 n. [生化] 组蛋白
例 句 Histones are proteins that regulate DNA packing, and histone deacetylases are enzymes that control the way those proteins work.组蛋白控制DNA折叠,而组蛋白去乙酰酶抑制剂是种控制这些蛋白质工作的酶。
acetyltransferase
释 义 乙酰转移酶,转乙酰酶
例 句 These help a mitochondrial enzyme called carnitine acetyltransferase to do its job.这两种分子有助于被称作肉碱乙酰转移酶的线粒体酶发挥作用。
概述
脉冲糖皮质激素通过表观遗传代谢重编程增强营养不良肌肉性能
发表时间:2019-12-01
影响因子:6.0
作者: Mattia Quattrocelli
期刊:JCI Insight
Tightly regulated control of muscle metabolism is essential to performance and the well being of the whole organism. With exercise, muscle coordinately upregulates the metabolism of glucose, fatty acids, and amino acids for energy production, and this response varies with time of day. In Duchenne Muscular Dystrophy (DMD), loss of dystrophin produces a fragile muscle membrane, leading to muscle degeneration. In addition to the primary loss of dystrophin, muscle mitochondrial function and ATP synthetic capacity are secondarily impaired. Glucocorticoid (GC) steroids are used in DMD, where their use prolongs ambulation.
译文