Recombinant urate oxidase (rasburicase) in the prevention and treatment of malignancy-associated hyperuricemia in pediatric and adult patients: results of a compassionate-use trial.
重组尿酸氧化酶 (rasburicase) 在预防和治疗儿童和成人患者恶性肿瘤相关的高尿酸血症: 同情使用试验的结果。

摘要

To confirm the efficacy of recombinant urate oxidase (rasburicase) and to establish its safety profile, we reviewed the data on 173 children and 72 adults with malignancy who were treated with this new uricolytic agent in a compassionate-use trial. Rasburicase (0.20 mg/kg) was administered intravenously daily for 1 to 7 days and could be given every 12 h for the initial 72 h. Subsequent courses were allowed at a later date. Rasburicase produced a dramatic decrease in uric acid concentrations in all patients whether they received it for prophylaxis (n = 79) or treatment (n = 166) (P < 0.001 in all comparisons between the levels at diagnosis and those after treatment). The median post-treatment levels were 0.5 to 0.7 mg/dl. Repeated administrations were also effective in all 11 evaluable patients. Four children and five adults had mild adverse reactions that were drug related or of unknown etiology. In two of the children, the adverse events occurred during the second course. Rasburicase is highly effective and safe in the prophylaxis or treatment of malignancy- or chemotherapy-associated hyperuricemia in children and adults.

译文

为了确认重组尿酸氧化酶 (rasburicase) 的功效并建立其安全性简介, 我们回顾了 173 名儿童和 72 名成人恶性肿瘤患者的数据,他们在一项同情性试验中接受了这种新型尿毒剂的治疗。Rasburicase (0.20 mg/kg) 每天静脉给药 1 至 7 天,最初 72 小时可以每 12 小时给药一次。随后的疗程允许在以后进行。无论是接受预防 (n = 79) 还是治疗 (n = 166),Rasburicase 都会在所有患者中产生尿酸浓度的急剧下降 (在诊断和治疗后的水平之间的所有比较中 P <0.001)。治疗后水平的中位数为 0.5 至 0.7 mg/dl。重复给药对所有 11 名可评估患者也有效。4 名儿童和 5 名成人有轻微的药物相关或病因不明的不良反应。其中两个孩子的不良事件发生在第二个疗程。Rasburicase 在预防或治疗儿童和成人恶性肿瘤或化疗相关性高尿酸血症方面非常有效和安全。

Urate oxidase

内分泌 临床研究术语
概述  :  

尿酸氧化酶(UO)在人类中主要存在于肝脏,在许多过氧化物酶体中,它形成一个大的电子致密副晶核。该酶以相同亚基的四聚体形式存在,每个亚基均包含一个可能的2型铜结合位点。 反应机制 尿酸氧化酶是三种酶将尿酸转化为S-(+)-丙氨酸的途径中的第一个。尿酸氧化酶将尿酸转化为5-羟基异羟乙酸后,HIU 水解酶将5-羟基异羟乙酸(HIU)转化为2-氧代-4-羟基-4-羧基-5-脲基咪唑啉(OHCU),然后再转化为S-( +)-丙氨酸通过2

urate   英 /'jʊəreɪt/   美 /'jʊr,et/

释    义   n. [生化] 尿酸盐

例    句   Advanced gout. Untreated gout may cause deposit of urate crystals to form under the skin in nodules called tophi (TOE-fi).未经治疗的痛风会使皮肤下沉积尿酸结石从而形成结节,成为结节瘤。

 

oxidase   英 /'ɒksɪdeɪz/

释    义   n. [生化] 氧化酶

例    句   This defense takes place inside cells by an enzyme called Mixed Function Oxidase.这种防御是通过细胞内部一种叫做混合功能氧化酶来完成的。


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