内分泌
词汇介绍
拓展阅读
解析
oxidative 英 /'ɒksɪdeɪtɪv/ 美 /,ɑksə'detɪv/
释 义 adj. [化学] 氧化的
同根词 oxidized adj. 被氧化的;生锈的
oxidation n. [化学] 氧化
oxidized v. 氧化;生锈(oxidize的过去分词)
oxidize vi. 氧化
oxidize vt. 使氧化;使生锈
例 句 Robertson: Oxidative stress is an accumulation of molecules that comes about because of chemical reactions, or stuff we ingest, things that get in our body.罗伯逊:氧化应激是一种由化学反应或我们摄取的东西—即被我们身体吸收的物质—造成的毒性分子堆积。
stress 英 /stress/ 美 /stress/
释 义 n. 压力;强调;紧张;重要性;重读
vt. 强调;使紧张;加压力于;用重音读
同根词 adj. stressful 紧张的;有压力的
n. stressor 紧张性刺激;光彩
例 句 The sadness, stress, pain, or anger is there whether you like it or not.不管你喜欢不喜欢,悲伤、压力、痛苦或愤怒都在那儿。
概述
氧化应激介导高咖啡因摄入诱导的斑马鱼焦虑样行为: α-生育酚的保护作用
发表时间:2019-10-01
影响因子:4.9
作者: Tayana Silva de Carvalho
期刊:Oxid Med Cell Longev
The broad effects of caffeine in CNS occur via nonspecific inhibition of adenosine receptors expressed either in neurons or in glial cells. As previously described, low doses of caffeine antagonize A2a adenosine receptors, promoting motor changes and anxiolytic-like behavior responses. On the other hand, it was also demonstrated that high doses of caffeine may induce anxiogenic-like behavior by unclear mechanisms. In addition, the effect of caffeine on other neurotransmitter systems has been previously described in the literature. It is well described that caffeine is able to modulate the extracellular levels of glutamate as well as to prevent oxidative stress in the brain. Although it is widely showed that glutamate and reactive oxygen species (ROS) lead to neurobehavioral alterations, it remains unclear if brain oxidative stress represents a biochemical mechanism involved in anxiety-like behavior evoked by caffeine. Alpha-tocopherol is a chemical form of vitamin E which has potent antioxidant activity. As confirmed in previous studies, alpha-tocopherol possess high liposolubility and easily crosses the blood-brain barrier. This chemical property assures its effect on the CNS, even after a systemic administration. In case of alpha-tocopherol deficiency, increased anxietylike behavior was previously reported in experimental studies. Based on these evidences, it is reasonable to hypothesize that alpha-tocopherol can exert a neuroprotective role against the deleterious effects of caffeine on the CNS.
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