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首页 > 医学词汇大全 > Oxidative stress
Oxidative stress

内分泌

关键词内分泌 临床研究术语 生化反应

词汇介绍

拓展阅读

解析

oxidative   英 /'ɒksɪdeɪtɪv/   美 /,ɑksə'detɪv/

释    义   adj. [化学] 氧化的

同根词   oxidized adj. 被氧化的;生锈的

               oxidation n. [化学] 氧化

               oxidized v. 氧化;生锈(oxidize的过去分词)

               oxidize vi. 氧化

               oxidize vt. 使氧化;使生锈

例    句   Robertson: Oxidative stress is an accumulation of molecules that comes about because of chemical reactions, or stuff we ingest, things that get in our body.罗伯逊:氧化应激是一种由化学反应或我们摄取的东西—即被我们身体吸收的物质—造成的毒性分子堆积。

 

stress   英 /stress/   美 /stress/

释    义   n. 压力;强调;紧张;重要性;重读

               vt. 强调;使紧张;加压力于;用重音读

同根词   adj. stressful 紧张的;有压力的

               n. stressor 紧张性刺激;光彩

例    句   The sadness, stress, pain, or anger is there whether you like it or not.不管你喜欢不喜欢,悲伤、压力、痛苦或愤怒都在那儿。

概述

氧化应激反映了活性氧的系统表现与生物系统易于将活性中间体解毒或修复所造成的损害的能力之间的不平衡。细胞正常氧化还原状态的紊乱可通过产生过氧化物和自由基而引起毒性作用,这些过氧化物和自由基会破坏细胞的所有成分,包括蛋白质,脂质和DNA。氧化代谢产生的氧化应激会导致碱基损伤以及DNA链断裂。进一步,一些反应性氧化性物质作为氧化还原信号传导细胞信使。因此,氧化应激可导致细胞信号传导正常机制的破坏。 疾病相关 氧化应激被怀疑是在重要的

Oxidative Stress Mediates Anxiety-Like Behavior Induced by High Caffeine Intake in Zebrafish: Protective Effect of Alpha-Tocopherol复制标题

氧化应激介导高咖啡因摄入诱导的斑马鱼焦虑样行为: α-生育酚的保护作用

发表时间:2019-10-01

影响因子:4.9

作者: Tayana Silva de Carvalho

期刊:Oxid Med Cell Longev

The broad effects of caffeine in CNS occur via nonspecific inhibition of adenosine receptors expressed either in neurons or in glial cells. As previously described, low doses of caffeine antagonize A2a adenosine receptors, promoting motor changes and anxiolytic-like behavior responses. On the other hand, it was also demonstrated that high doses of caffeine may induce anxiogenic-like behavior by unclear mechanisms. In addition, the effect of caffeine on other neurotransmitter systems has been previously described in the literature. It is well described that caffeine is able to modulate the extracellular levels of glutamate as well as to prevent oxidative stress in the brain. Although it is widely showed that glutamate and reactive oxygen species (ROS) lead to neurobehavioral alterations, it remains unclear if brain oxidative stress represents a biochemical mechanism involved in anxiety-like behavior evoked by caffeine. Alpha-tocopherol is a chemical form of vitamin E which has potent antioxidant activity. As confirmed in previous studies, alpha-tocopherol possess high liposolubility and easily crosses the blood-brain barrier. This chemical property assures its effect on the CNS, even after a systemic administration. In case of alpha-tocopherol deficiency, increased anxietylike behavior was previously reported in experimental studies. Based on these evidences, it is reasonable to hypothesize that alpha-tocopherol can exert a neuroprotective role against the deleterious effects of caffeine on the CNS.

译文

咖啡因在中枢神经系统的广泛作用是通过对神经元或胶质细胞中表达的腺苷受体的非特异性抑制来实现的。如前所述,低剂量咖啡因拮抗A2A腺苷受体,促进运动变化和焦虑样行为反应。 另一方面,还表明,高剂量的咖啡因可能引起焦虑样行为的机制不明。此外,咖啡因对其他神经递质系统的影响在文献中已有描述。很好地描述了咖啡因能够调节谷氨酸的细胞外水平以及防止大脑中的氧化应激。虽然广泛显示谷氨酸和活性氧(ROS)导致神经行为改变,但目前尚不清楚脑氧化应激是否是一种涉及咖啡因诱发的焦虑样行为的生化机制。 α-生育酚是维生素E的一种化学形式,具有很强的抗氧化活性。正如先前的研究所证实的,α-生育酚具有高脂溶性,很容易穿过血脑屏障。这种化学性质保证了它对中枢神经系统的影响,即使在全身给药后也是如此。在α-生育酚缺乏的情况下,增加的焦虑样行为先前报道的实验研究。基于这些证据,我们有理由假设α-生育酚可以对咖啡因对中枢神经系统的有害影响发挥神经保护作用。