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首页 > 医学词汇大全 > Hypomagnesemia
Hypomagnesemia

内分泌

关键词内分泌 疾病 电解质紊乱

词汇介绍

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解析

hypomagnesemia   英 /'haipə,mæɡnə'si:miə/

释    义   n. (美)低镁症;(尤指牛的)血镁过少

例    句   The incidence of hypomagnesemia was significantly higher in patients with arrhythmias than those without, the percentages of incidence were 83.9 and 26.6 (P<0.001) respectively.在这些心律失常患者中,低镁血症明显多于无心律失常患者,分别占83.9%与26.6%(P<0.001)。

概述

镁缺乏症是一种电解质紊乱,其中体内的镁含量较低,它可能导致多种症状,症状包括震颤,协调不力,肌肉痉挛,食欲不振,性格改变和眼球震颤等,并发症可能包括癫痫发作或心脏骤停,例如来自尖端扭转型室速。镁含量低的人常常钾含量也低。原因包括低饮食摄入,酗酒,腹泻,肠道吸收不良和糖尿病等,许多药物也可能引起低镁血症。原因①药物:噻嗪类利尿剂的使用;抗生素的使用;长期使用质子泵抑制剂。②遗传学:Gitelman样疾病,其包括引起综合征遗传突变在SLC12A3,CLNCKB, BSND,KCNJ10,FXYD

Hypomagnesemia is associated with new-onset diabetes mellitus following heart transplantation复制标题

心脏移植后低镁血症与新发糖尿病相关

发表时间:2019-10-11

影响因子:6.0

作者: Yael Peled

期刊:Cardiovasc Diabetol

Another unfavorable post-HT occurrence may be the development of a magnesium deficiency, to which a possible contributory factor is the administration of calcineurin inhibitors (CNIs), which are known to induce magnesium urinary wasting. Moreover, MiR133a-regulated calcineurin-nuclear factor in activated T cells c4 (NFATc4) signialling and DNA methyltransferases-1 (DNMTs-1)-3a is changed in diabetic hearts and has been shown to be associated with a hypertrophic response and cardiac remodeling. Indeed, it has been reported that hypomagnesemia frequently develops within the first few weeks following kidney transplantation, with a nadir in the serum magnesium (s-Mg) level in the second month post-transplantation and persistent hypomagnesemia is invariably accompanied by myocardial magnesium depletion in the transplanted heart. Several studies have indicated that magnesium deficiency is nonetheless a potentially modifiable risk factor for diabetes in both non-transplant patients and in kidney transplant recipients; it is also known that magnesium in the high-normality range is associated with a lower cardiovascular risk and its levels are independently and inversely associated with prediabetes and overt diabetes. The molecular basis for the involvement of magnesium in the pathogenesis of diabetes may lie in its role as a co-factor in several pathways, including glucose transport and insulin sensitivity and secretion. In healthy individuals, binding of insulin to insulin receptor in  vitro leads to translocation of magnesium to platelets, leading to reduced platelet aggregation and decreased release of pro-aggregatory agents like thromboxane; this protective effect is lost in diabetics.

译文

HT后发生的另一种不利情况可能是镁缺乏症的发展,其可能的促成因素是钙调神经磷酸酶抑制剂(CNIs)的给药,已知它会导致镁尿浪费。此外,在糖尿病心脏中,MiR133a调节的活化T细胞c4(NFATc4)信号和DNA甲基转移酶-1(DNMTs-1)-3a中的钙调神经磷酸酶核因子发生改变,并已显示与肥大反应和心脏重塑有关。确实,据报道,低镁血症经常在肾脏移植后的最初几周内发展,在移植后的第二个月血清镁(s-Mg)水平达到最低点,而持续的低镁血症总是伴随着心肌镁耗竭。心脏移植几项研究表明,无论是非移植患者还是肾移植接受者,镁缺乏症都是糖尿病的潜在危险因素。还已知,高正常范围的镁与较低的心血管风险有关,其水平与糖尿病前期和明显的糖尿病独立地且相反地相关。镁参与糖尿病发病机制的分子基础可能在于其作为多种途径的辅助因子,包括葡萄糖转运,胰岛素敏感性和分泌。在健康个体中,胰岛素与胰岛素受体的体外结合会导致镁易位至血小板,从而导致血小板聚集减少和血栓烷等促凝剂的释放减少;糖尿病患者失去了这种保护作用。