Lipopolysaccharide 英 /ˌlʌɪpəʊpɒlɪˈsakərʌɪd/ 美 /ˌlʌɪpəʊpɒlɪˈsakərʌɪd/
释 义 n. [有化] 脂多糖
例 句 It recognizes lipopolysaccharide, a component of the outer membrane of Gram-negative bacteria. 它识别广泛存在革兰氏阴性菌细胞外膜上的脂多糖。
作者： Patrick C Baer
Recent data have suggested that adipose tissue located in different anatomical locations of the body appear to have distinct cellular compositions and diverse functions. In humans, fat depot-specific differences are clinically relevant owing to the observation that increased abdominal white fat is associated with insulin resistance, while subcutaneous white adipose tissue exerts a protective effect against metabolic syndrome. Para- and perirenal adipose tissue is a fat pad located in the retroperitoneal space. Perirenal fat is separated from pararenal fat by the renal fascia, and surrounds each kidney. It is a collection of adipose tissue located superficial to the renal cortex and is part of the visceral fat, which can be divided into perirenal, gonadal, epicardial, retroperitoneal, omental and mesenteric fat depots. They are composed mainly of white adipose cells that store energy and produce soluble inflammatory cytokines. Perirenal fat shares the same developmental origin as typical visceral fat. However, each white adipose tissue depot can be described as a separate mini-organ, and perirenal fat and typical visceral fat are different in histology, physiology and functions. The vascularization of perirenal adipose tissue grows from branches of the abdominal aorta, which also supplies blood to the kidney cortex. Therefore, effects on renal cells through soluble factor released by cells from the perirenal adipose tissue are possible. Renal adipose tissue has been linked recently to effects on kidney function and blood hypertension and a neuronal link from perirenal adipose tissue to multiple central nervous system’s regions has been shown in animal data. Perirenal tissue is rarely analyzed for viral infections, however MSC from selected organs other than perirenal tissue show susceptibility and permissiveness for human cytomegalovirus (HCMV) infection. The object of this study was to describe the isolation and culture of human perirenal adiposederived stromal/stem cells (prASCs) in detail and to characterize cultured cells and their differentiation potential into adipocytes, chondrocytes, osteoblasts and epithelial cells. The present study further investigated the immunomodulatory potential of prASCs after stimulation with lipopolysaccharide (LPS), lipoteichoic acid (LTA), a mixture of cytokines (cytomix), or infection with HCMV. Whereas, few studies used human prASCs in vitro, there is currently no other study which fully described the isolation, characterization, differentiation and immunomodulatory potential of human prASCs as well as their susceptibility to HCMV.