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Strontium ranelate

内分泌

关键词内分泌 治疗药物 雷奈酸

词汇介绍

拓展阅读

解析

Strontium   英 /ˈstrɒntiəm; ˈstrɒnʃiəm/   美 /ˈstrɑːntiəm,ˈstrɑːnʃiəm/  

释    义   n. [化学] 锶

例    句   This paper described the determination of strontium in mineral water by flame atomic emission spectrometry in the emission mode of AAS. 本文介绍了用原子吸收光谱仪的发射方式火焰原子发射光谱法直接测定矿泉水中锶。

 

Ranelate

释    义   雷奈

例    句   A lot of animal experiments and clinical trials have proven that strontium ranelate not only can prevent bone absorption but also promote bone formation. 大量的动物实验和临床试验研究表明雷奈酸锶是一种既具有抗骨吸收,又能促进骨形成的药物。

概述

雷奈酸锶,一个具有锶(II)盐的雷奈酸,可以减缓膝盖骨关节炎的病程。该药物是不寻常的,因为它既增加了成骨细胞对新骨的沉积,又减少了破骨细胞对骨的吸收。因此,它被推广为“双重作用的骨剂”(DABA)。作用机理锶的原子符号为Sr,原子序数为38,属于元素周期表中的第二族,仅次于钙。由于其核的大小与钙的大小几乎相同,因此人体很容易吸收锶,并将其掺入骨骼和牙釉质中以代替钙。雷奈酸锶是一种抗骨质疏松剂,可增加骨形成并减少骨吸收,从而导致骨转换平衡,有利于骨形成,这类似于胆碱稳定的原硅酸的作用。雷奈酸锶

Effects of strontium ranelate on ligature‐induced periodontitis in estrogen‐deficient and estrogen‐sufficient rats 复制标题

雷奈酸锶对雌激素缺乏和雌激素充足大鼠韧带诱导牙周炎的影响

发表时间:2019-09-20

影响因子:2.6

作者: Letícia Macedo Marins

期刊:J Periodontal Res

The destruction of the protective and supportive periodontal tissues during the course of periodontitis is a consequence of the interaction between pathogens and immunoinflammatory host responses. There is a continuous interest in identifying risk factors, such as lifestyles, systemic diseases, and medications, that can hinder or accelerate periodontal tissue destruction during periodontitis by modifying the periodontal microbial profile, host responses and/or alveolar bone metabolism. Estrogen deficiency appears naturally after menopause or as a result of early menopause or bilateral oophorectomies and has been identified as one of main causes of osteoporosis. The depletion of estrogen induces a significant imbalance in bone remodeling, with bone resorption exceeding bone formation. The main characteristics of osteoporosis are the reduction of bone mass and mineral contents, alterations in bone micro‐architecture, and increased risk of fractures. Due to the rising prevalence of osteoporosis, researchers and clinicians in the field of dentistry have focused on the study of the impact of osteoporosis on the different bone pathologies that affect the jawbones. In periodontics, clinical studies have suggested a positive association between the clinical and radiographic parameters of periodontitis and the parameters used for the diagnosis of osteoporosis. Studies in animals using ovariectomy‐induced estrogen deficiency models have shown that osteoporosis increases alveolar bone resorption in rats with and without ligature‐induced periodontitis. Currently, bisphosphonates are the most commonly used anti‐ resorptive agents for the treatment of osteoporosis; however, the initiation or continuation of bisphosphonate therapies has declined due to the risk of adverse effects including osteonecrosis of the jaw and atypical fractures. Hence, there is an unceasing search for medications that can effectively treat osteopenia/osteoporosis, reducing the fracture risk at all skeletal sites, with minimal contraindications, maximum tolerability, and the best risk‐benefit balance. During the last decade, several reports have investigated strontium ranelate as an antiosteoporosis drug due to its promising physicochemical and pharmacokinetic features. When compared to other drugs, strontium ranelate has a very peculiar dual action on bone tissues that simultaneously stimulates osteoblast recruitment and activity while the number, activity, and lifespan of osteoclasts are reduced, resulting in both anabolic and anti‐resorptive actions.

译文

牙周炎过程中保护性和支持性牙周组织的破坏是病原体与免疫炎症宿主反应之间相互作用的结果。人们一直对识别风险因素(例如生活方式,全身性疾病和药物)感兴趣,这些风险因素可以通过改变牙周微生物的形态,宿主反应和/或牙槽骨代谢来阻止或加速牙周炎期间牙周组织的破坏。绝经后或早期绝经或双侧卵巢切除术会自然而然地产生雌激素缺乏症,雌激素缺乏症已被认为是骨质疏松症的主要原因之一。雌激素的消耗会导致骨骼重塑失衡,导致骨骼吸收超过骨骼形成。骨质疏松症的主要特征是骨量和矿物质含量减少,骨微结构改变以及骨折风险增加。由于骨质疏松症的患病率上升,因此牙科领域的研究人员和临床医生已集中研究骨质疏松症对影响颌骨的不同骨病理学的影响。在牙周病中,临床研究表明,牙周炎的临床和放射学参数与用于诊断骨质疏松症的参数之间存在正相关。使用卵巢切除术诱导的雌激素缺乏模型对动物进行的研究表明,骨质疏松症可增加有或无结扎性牙周炎的大鼠的牙槽骨吸收。目前,双膦酸盐是治疗骨质疏松症最常用的抗吸收剂。但是,由于包括下颌骨坏死和非典型骨折在内的不良反应的风险,双膦酸盐治疗的开始或继续使用已经减少。因此,人们一直在寻找能够有效治疗骨质疏松/骨质疏松症,减少禁忌症,最大的耐受性和最佳的风险效益平衡的,能减少所有骨骼部位骨折风险的药物。在过去的十年中,由于雷奈酸锶具有良好的理化和药代动力学特性,已有几篇报道对雷奈酸锶作为抗骨质疏松药物进行了研究。与其他药物相比,雷奈酸锶对骨组织具有非常独特的双重作用,同时刺激成骨细胞的募集和活动,同时破骨细胞的数量,活性和寿命减少,从而导致合成代谢和抗吸收作用。