摘要

Clinical Question:Among patients with multiple myeloma, is bisphosphonate therapy associated with lower rates of mortality, vertebral fractures, nonvertebral fractures, and skeletal-related events compared with placebo or no treatment?
Bottom Line:Among patients with myeloma, bisphosphonates were associated with lower rates of pathological fractures and skeletal-related events compared with placebo or no treatment. Direct meta-analysis showed no association between bisphosphonates and mortality. In network meta-analysis, zoledronate was associated with lower risk of mortality compared with placebo or no treatment.

译文

临床问题: 在多发性骨髓瘤患者中,与安慰剂或不治疗相比,双磷酸盐治疗与较低的死亡率、椎骨骨折、非椎骨骨折和骨骼相关事件相关吗?
底线: 与安慰剂或不治疗相比,在多发性硬化症患者中,双磷酸盐与较低的病理性骨折和骨骼相关事件发生率相关。直接荟萃分析显示双膦酸盐与死亡率之间没有关联。在网络荟萃分析中,唑来膦酸钠与安慰剂或不治疗相比,死亡率风险较低。

Bisphosphonates

内分泌 防止骨密度降低 治疗药物
概述  :  

双膦酸盐是一类防止骨密度降低的药物,用于治疗骨质疏松症和类似疾病。它们是用于治疗骨质疏松症的最常用处方药。双膦酸盐的用途包括预防和治疗骨质疏松症,骨转移(有或没有高钙血症),多发性骨髓瘤,原发性甲状旁腺功能亢进,成骨不全症,纤维异常增生以及其他表现出骨脆性的疾病。临床应用双膦酸盐用于治疗骨质疏松症,变形性骨炎(骨骼的佩吉特氏病),骨转移(伴或不伴高钙血症),多发性骨髓瘤和其他涉及脆弱,易碎的骨骼的疾病。在骨质疏松症和佩吉特氏症中,最常使用的一线双膦酸盐药物是阿仑膦酸盐和利塞膦酸盐。如果这些方

Bisphosphonates  

释    义   双磷酸盐

例    句   She picked the drugs because of studies in humans that suggest bisphosphonates may help prevent cancer from spreading to the bone.她之所以选择这些药物是因为在人类研究中表明双磷酸盐可以帮助阻止癌症扩散到骨骼。

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