微信扫码关注“小狗文献”

即刻体验更多权益

文献多,下载快,翻译准

首页 > 医学词汇大全 > Cholestyramine
Cholestyramine

内分泌

关键词内分泌 治疗药物 螯合剂

词汇介绍

拓展阅读

解析

Cholestyramine   英/,kolɪ'stɪrə,min; ko,lɛstə'ræmin/   

释    义   n. 消胆胺

例    句   The latter effects can be attributed to the high bile acid-binding capacity of cholestyramine.其后两个作用归因于消胆胺具有较高的结合胆汁酸的能力。

概述

考来烯胺是一种胆汁酸多价螯合剂,其在胃肠道中结合胆汁,以防止其再吸收。它是一种强离子交换树脂,这意味着它可以与胃肠道中的阴离子胆汁酸交换其氯 离子,并将它们牢固地结合在树脂基质中。阴离子交换树脂的官能团是季铵盐铵基与惰性苯乙烯-二乙烯基苯共聚物相连。考来烯胺通过与肠道内的胆汁酸形成不溶的配合物从而从体内清除胆汁酸,然后排泄在粪便中,进而使得更多的血浆胆固醇在肝脏中转化为胆汁酸以恢复至正常水平。胆固醇向胆汁酸的这种转化降低了血浆胆固醇水平。临床应用胆汁酸螯合剂(例如秋水仙碱)首先用于治疗高胆固

Evaluation of Cholestyramine 15% Ointment in Relieving Pruritus and Burning After Ileostomy:A Rrandomized, Double-Blind Placebo-Controlled Clinical Trial 复制标题

15% 消胆胺软膏缓解回肠造口术后瘙痒和烧伤的评价: 随机、双盲、安慰剂对照临床试验

发表时间:2019-03-20

影响因子:1.6

作者: Shahram Ala

期刊:J Invest Surg

An ileostomy may be required for the management of different pathologic conditions. Anatomic location and the type of stoma construction can have significant effects on the management of this surgical procedure. The type and content of the output and the fluid loss are distinguished by the location of the stoma relative to the ileocecal valve. Fluid loss is primarily a factor with end or loop ileostomies. With proper stoma care, most ostomy patients can have active, healthy, personal, and professional lives. After an ileostomy, a special bag is put over the stoma to collect waste products. Although there has been much progress regarding the treatment of ileostomy so far, there are still many problems in this domain. The patient must be accustomed to the new patterns of fecal elimination, body change, and the image of him/herself. The most common early complications include skin irritation, pain, and necrosis. However, the most common late problems are skin irritation and prolapse. Even if an ileostomy is performed properly, the leakage of the intestinal discharge around the stoma can occasionally happen. This results in the initiation of troublesome skin irritation; therefore, the main complication is regarded as inflammation (e.g. irritant contact dermatitis), which presents by burning and pruritus. The inflammation appears to result from the high level of bile acid, which is present in the ileal fluid with powerful purifying and pruritogenic properties. Free bile acids have been proved to produce intestinal mucosal cell damage in laboratory animals .

译文

回肠造口术可能需要处理不同的病理条件。解剖位置和造瘘口的类型对手术操作有重要影响。根据造瘘口相对于回盲瓣的位置,可以区分出排出量和失水量的类型和含量。液体流失是回肠末端或环状造口的主要因素。有了正确的造口护理,大多数造口术患者都可以拥有积极、健康、个人和专业的生活。回肠造口术后,在造口上放一个特殊的袋子来收集废物。回肠造口术的治疗虽然取得了很大进展,但仍存在许多问题。病人必须习惯新的排便模式、身体变化和他/她自己的形象。最常见的早期并发症包括皮肤刺激、疼痛和坏死。然而,最常见的晚期问题是皮肤刺激和脱垂。即使回肠造口术做得很好,造口周围的肠道分泌物也会偶尔发生渗漏。这会引起麻烦的皮肤刺激;因此,主要并发症被视为炎症(如刺激性接触性皮炎),表现为灼烧和瘙痒。炎症似乎是由于胆汁酸的高水平,它存在于回肠液中,具有强大的净化和瘙痒特性。在实验动物中,游离胆汁酸已被证明能引起肠粘膜细胞损伤。