释 义 n. 罗格列酮；梵帝雅
例 句 But they say that despite these limitations, patients and providers should consider the potential for serious adverse cardiac effects of treatment with rosiglitazone.但他们说，尽管有这些限制，病人和供者应考虑到用罗格列酮治疗中潜在的严重不良的心脏治疗。
作者： Sivandzade F
期刊：Int J Mol Sci
A vast number of deaths worldwide, are attributed to smoking, as a consequence of its effects on the vascular system in the body. As a major component of the vascular system, the endothelial cells are significantly impaired as a result of exposure to the toxic chemicals, free radicals, aromatic compounds and nicotine contained within tobacco smoke (TS). Endothelial function is critical to maintain the integrity, homeostasis and detoxifying role of the blood–brain barrier (BBB). The exact components of cigarette smoke and the mechanism of the pathophysiological link between smoking and vascular injury are not fully specified. The mechanism of vascular damage induced by cigarette smoking is multifaceted; dysfunction of the BBB through activation of oxidative, inflammatory and immune responses leads to pathogenesis and progression of cerebrovascular and neurodegenerative disorders, including stroke, Alzheimer’s disease (AD), Parkinson disease (PD), amyotrophic lateral sclerosis (ALS), depression, vascular dementia and Huntington’s disease (HD). In fact, the selectivity of the BBB, a dynamic and complex interface between the blood and the central nervous system (CNS), allows some nutrients to transport between the peripheral circulation and the brain, while it prevents many toxic compounds and pathogens from entering the brain. There is now a wealth of evidence suggesting the major role of oxidative stress in endothelial dysfunction in the cerebrovascular level. Despite the valid evidence for the significant link between cigarette smoking and vascular impairment, the impact of TS exposure on the BBB has not been completely addressed. In the recent work of our group, the involvement of common pathogenic modulators of BBB impairment was confirmed so that chronic cigarette smoking and hyperglycemia (HG) carried similar risks for cerebrovascular diseases and stroke, sharing similar pathogenic mechanisms. This result accounts for the reason for the possible application of anti-diabetic drugs to prevent/reduce BBB damage promoted by the chronic TS exposure. Rosiglitazone (RSG) is a member of the thiazolidinedione family of antidiabetic agents that can improve insulin sensitivity through modulating adiponectin gene expression in muscle and adipose tissue, and inhibits hepatic gluconeogenesis. RSG is also considered as a potent and selective transcription factor peroxisome proliferator-activated receptor (PPARγ) agonist which is a nuclear receptor that regulates numerous genes implicated in glucose homeostasis, and fatty acid metabolism. In humans, PPAR receptors are found in key target tissues for insulin action, such as adipose tissue, skeletal muscle, and liver. Despite the unknown mechanism of RSG, numerous studies and our previous work has confirmed the protective effect of RSG against oxidative damage. The aim of the present study is to validate and assess the previous results using animal models in vivo and to confirm RSG’s role in the activation of counteractive antioxidative mechanisms to reduce TS toxicity at the BBB.