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Hypermagnesemia

内分泌

关键词内分泌 疾病 电解质紊乱

词汇介绍

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解析

Hypermagnesemia

释    义   n. 高镁血症

例    句   There is no hypermagnesemia with apparent clinical effect by these doses of magnesium sulfate during operation. 应用本实验剂量的硫酸镁不会造成有临床效应的高镁血症。

概述

高镁血症是一种电解质紊乱,血液中的镁含量很高。症状包括虚弱,神志不清,呼吸频率降低和反射减弱,并发症可能包括低血压和心脏骤停。它通常是由肾衰竭引起的,或者是采用诸如含镁的抗酸剂的治疗引起的。不太常见的原因包括肿瘤溶解综合征,癫痫发作和长时间的缺血。原因镁的状态取决于三个器官:肠道中的摄取,骨骼中的储存和肾脏中的排泄。因此,高镁血症通常是由于这些器官(主要是肠道或肾脏)的问题引起的。溶血,红细胞中的镁浓度大约是血清中的三倍,因此溶血会增加血浆中的镁。肌酐清除率低于30 ml/min 时,慢性肾

Hypermagnesemia disturbances in rats, NO-related: pentadecapeptide BPC 157 abrogates, L-NAME and L-arginine worsen复制标题

大鼠高镁血症紊乱,无相关性: 十五肽BPC 157 abrogates,L-NAME和L-精氨酸恶化

发表时间:2017-08-25

影响因子:3.8

作者: Maria Medvidovic-Grubisic

期刊:Inflammopharmacol

The beneficial effect of pentadecapeptide BPC 157 (no muscle weakness, markedly counteracted brain lesions, lessened hypermagnesemia, maintained normokalaemia) is common for a lg–ng/kg dose range and is significant, because the same doses used and beneficial effects were previously noted. Furthermore, combined hyperkalaemia/hypermagnesemia consistently appeared along with worsening and then disappeared with amelioration, indicating that clearly attenuated hypermagnesemia/maintained normokalaemia is suggestive that BPC 157 might, here, also counteract the initial event leading to hypermagnesemia. A supportive analogy is the counteraction of magnesium sulfate-induced writhing that also appears rapidly and is quite specific as it is unaffected by anti-inflammatory drugs (including serotonin and histamine receptor antagonists) and is unaccompanied by prostaglandin release. This effect, along with the illustrative evidence, implies all of the counteracting effects mentioned before (i.e., on paralysis, arrhythmias, and hyperkalaemia, and extreme muscle weakness; parasympathetic and neuromuscular blockade; injured muscle). In contrast, with a worsened course, higher hypermagnesemia, and emerging hyperkalaemia, it is likely that both LNAME and L-arginine might adversely affect the same events (and that these could be again opposed by BPC 157). Also, the BPC 157 beneficial effects in rats overdosed with magnesium should be considered with respect to its possible effect on the evidenced Mg2+ homeostasis tightly controlled by maintaining the equilibrium between intestinal Mg2+ absorption and renal Mg2+ excretion/reabsorption and several Mg2+ transporters and channels implicated in Mg2+ absorption and/or re-absorption.

译文

五肽肽BPC 157的有益作用(无肌肉无力,明显的脑损伤,高镁血症减轻,维持正常的血钾血症)在lg-ng / kg剂量范围内很常见,并且是显着的,因为之前已指出了相同的剂量和有益作用。此外,合并的高钾血症/高镁血症在出现恶化的同时不断出现,然后随着改善而消失,这表明明显减弱的高镁血症/维持的正常钾血症提示BPC 157在此也可以抵消导致高镁血症的最初事件。支持类比是硫酸镁诱导的扭动的反作用,这种反作用也很快出现,并且非常特异性,因为它不受抗炎药(包括5-羟色胺和组胺受体拮抗剂)的影响,并且与前列腺素的释放无关。该作用与说明性证据一起暗示了前面提到的所有抵消作用(即对瘫痪,心律不齐和高钾血症以及极端的肌肉无力;副交感神经和神经肌肉阻滞;受伤的肌肉)。相反,随着病情恶化,高镁血症和新出现的高钾血症,LNAME和L-精氨酸都可能对同一事件产生不利影响(并且BPC 157可能再次反对这些事件)。同样,应考虑BPC 157对过量服用镁的大鼠的有益作用,即通过维持肠Mg2 +吸收和肾脏Mg2 +排泄/再吸收之间的平衡以及对Mg2 +转运蛋白和通道的影响,可以严格控制Mg2 +稳态对证据的影响。 Mg2 +吸收和/或再吸收。