Hyperphosphatemia 英 /:haipəfɔsfə'ti:mjə/
释 义 n. [医] 血磷酸盐过多；[医] 高磷酸盐血
例 句 Objective: To investigate the clinical characteristics and mechanism of renal failure due to acute hyperphosphatemia following intravenous fructose diphosphate injection. 目的：探讨注射用二磷酸果糖致急性高磷血症的临床特点及诱发急性肾功能衰竭的发病机理。
作者： Nada Salhab
Hyperphosphatemia, described as the “silent killer” for hemodialysis (HD) patients, is prevalent among almost half of this population and is a determinant to decreased quality of life (QOL). The Kidney Disease Improving Global Outcomes (KDIGO) guidelines (2017) recommend lowering the serum phosphorus (P) levels towards the range that is considered normal for healthy populations. Standard HD regimes of 4-h three times a week cannot remove the entire P load; thus, other serum P controlling interventions are used such as limiting dietary P intake and administration of P-binding medications. However, these techniques provide some risks: the P-restricted diet can lead to protein energy malnutrition, and P-binders can cause gastrointestinal side effects, which may increase the cost of health care. This is a specific concern because there is no conclusive evidence about P-binder cost-effectiveness as first-line intervention for hyperphosphatemia management. All of which raises the need for adjunct novel effective approaches targeting hyperphosphatemia management, such as intradialytic exercise (IDE). Recently, 2 meta-analyses showed that exercise does not appear to have a significant impact on serum P compared to controls; however, most of the studies included in these reviews were relatively short term. IDE has been the focus of many researchers for the last two decades. Orcy et al. (2014) reported an increase in P clearance with IDE among HD patients. Also, other studies showed a decrease in serum P levels with IDE. It is hypothesized that exercise increases blood flow and decreases inter-compartmental resistance leading to increased toxin removal through the dialyzer. Moreover, IDE potentially has a positive effect on patient’s QOL, dialysis adequacy (Kt/V), urea reduction ratio (URR), C-reactive protein (CRP) levels, and functional capacity. Finally, in HD patients, body composition is significantly associated with physical functioning and QOL; thus, any attempt targeting muscle and fat distribution should be encouraged.